Catalytic Asymmetric[4+2]Cyclization of Hydroxyphenyl Indolinone with Azlactone to Construct Spirooxindoleδ-Lactone  

作　　者：Xuerui Wang Weiwu Ren 

机构地区：[1]Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,5 Yushan Road,Qingdao,Shandong,266003 China [2]Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center,Qingdao,Shandong,266237 China

出　　处：《Chinese Journal of Chemistry》2024年第24期3362-3366,共5页中国化学(英文版)

基　　金：We thank the Qingdao Marine Science and Technology Center(No.2022QNLM030003-2);the Fundamental Research Funds for the Central Universities,Taishan Scholar Program of Shandong Province(No.tsqn201909056);National Natural Science Foundation of China(No.22171251)for financial support.

摘　　要：An efficient asymmetric[4+2]cyclization of hydroxyphenyl indolinone with azlactone for the synthesis of spirooxindoleδ-lactone has been developed,which realized the first asymmetric reaction of hydroxyphenyl indolinone.A series of intricate structures with congested vicinal quaternary chiral centers were provided in good yields with excellent enantioselectivities via the in situ generated o-QM from hydroxyphenyl indolinone.

关 键 词：Asymmetric synthesis Hydroxyphenyl indolinone AZLACTONE Spirooxindoleδ-lactone Quaternary stereocenter 

分 类 号：O62[理学—有机化学]