Electrochemical Carboarylation of Activated Alkenes with CO_(2)and Electron-deficient Aryl Bromides  

作　　者：Zhaoliang Yang Chunlei Liu Cheng Zhong Jianye Zhang Shengzhang Liu mingming Yu yangyang Li Hong Yi Aiwen Lei 

机构地区：[1]National Engineering Research Center for Carbohydrate Synthesis,Jiangxi Normal University,Nanchang,Jiangxi 330022,China [2]The Institute for Advanced Studies(IAS),College of Chemistry and Molecular Sciences Wuhan University,Wuhan,Hubei 430072,China [3]School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang,Jiangxi 330004,China [4]School of Chemistry and Chemical Engineering,Zhejiang Sci-Tech University,Xiasha West Higher Education District,Hangzhou,Zhejiang 310018,China

出　　处：《Chinese Journal of Chemistry》2024年第24期3367-3372,共6页中国化学(英文版)

基　　金：supported by the National Key R&D Program of China(2022YFA1505100,2021YFA1500104);National Natural Science Foundation of China(22031008,22201222);Science Foundation of Wuhan(2023020201020266,2020010601012192);Jiangxi Normal University Doctoral Research Initiation Fund Project(12017081,12022796).

摘　　要：The simultaneous construction of two vicinal C—C bonds in a molecule remains a significant challenge.In this work,we disclose an electroreductive carboarylation of activated alkenes under mild,transition metal-free conditions.Utilizing readily available starting materials(electron-deficient aryl bromides,activated alkenes,and CO_(2)),this method demonstrates broad substrate scope and good functional group tolerance.Notably,this strategy enables the addition of two distinct electrophiles across an alkene in a highly chemo-and regioselective manner.

关 键 词：Electroreductive Difunctionalization Carboarylation Activated alkenes CO_(2) Aryl bromides 

分 类 号：O62[理学—有机化学]