Cross-Electrophile Couplings(XECs)between Similar Electrophile Reagents  

作　　者：Jie Lei Shan Yu Zhi-Gang Xu 

机构地区：[1]College of Pharmacy,National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics,IATTI,Chongqing University of Arts and Sciences,Chongqing 402160,China

出　　处：《Chinese Journal of Chemistry》2024年第24期3518-3532,共15页中国化学(英文版)

基　　金：the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202001338 and KJQN202101340);the Natural Science Foundation Project of CQ CSTSC(cstc2020jcyj-msxmX0733 and cstc2021jcyj-bsh0233).

摘　　要：Cross-electrophile couplings(XEC),a crucial subset of cross-coupling reactions,center on the formation of robust C—C bonds through the union of two electrophiles.Usually,such reactions have primarily been catalyzed by transition metals.However,with the steady advancements in photochemical and electrochemical technologies,XEC reactions have significantly progressed and broadened their scope,allowing for the utilization of a wider array of tolerable functional groups,thus revealing vast application prospects.This review aims to systematically summarize the current prevalent types of electrophiles and delve into their specific application examples within XEC reactions involving electrophiles with identical functional groups.Specifically,XECs between the same type of halides have received considerable attention,whereas carboxylic acids and alcohols are still in the early stages of investigation.Furthermore,certain other common electrophiles remain unexplored in this context.Moreover,this review underscores the remarkable contributions of photochemistry and electrochemistry in the field of XEC reactions,aiming to provide valuable insights and inspiration for researchers.Also,this review hopes to spark further interest in XEC reactions,thereby fueling the continuous development and advancement of this exciting area of research.

关 键 词：Cross-electrophile coupling(XEC) PHOTOCHEMISTRY Electrochemistry ELECTROPHILE C-C bond formation Synthetic methods CROSS-COUPLING Nickel 

分 类 号：O62[理学—有机化学]