中医证候动物模型建立及评价方法研究  

Research on Establishment and Evaluation Methods of Animal Model of TCM Syndromes

作　　者：杜利莉 章丹宁 薛梅[3] 卞勇[1] DU Lili;ZHANG Danning;XUE Mei;BIAN Yong(Laboratory Animal Center,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Integrated Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学实验动物中心,江苏南京210023 [2]南京中医药大学药学院,江苏南京210023 [3]南京中医药大学中西医结合学院,江苏南京210023

出　　处：《南京中医药大学学报》2025年第1期11-18,共8页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82274116,82474096)。

摘　　要：中医证候动物模型是揭示中医基础理论、促进中医药临床发展的重要载体,更是促进中医药现代化与国际化不可或缺的重要工具。目前,中医证候动物模型建立方法多样,评价标准不一。基于五脏的主要生理功能,以临床常见的心气虚证、肝郁证、脾气虚证、肺气虚证、肾阳虚证为代表,总结分析近年来最常用的中医证候动物模型的构建及评价方法,为建立更为科学客观的中医证候动物模型构建方法及评价体系提供参考。Animal models of TCM syndromes are the important carriers of revealing the basic theory of traditional Chinese medicine(TCM)and promoting the clinical development of TCM,and are indispensable tools to promote the modernization and internationalization of TCM.At present,the establishment methods of TCM syndrome animal model are varied and the evaluation criteria are different.Based on the main physiological functions of the five viscera,this paper summarized and analyzed the construction and evaluation methods of the most commonly used animal models of TCM syndromes in recent years,represented by the common clinical heart-qi deficiency syndrome,liver stagnation syndrome,spleen-qi deficiency syndrome,lung-qi deficiency syndrome and kidney-yang deficiency syndrome,in order to provide reference for establishing a more scientific and objective animal model construction method and evaluation system of TCM syndromes.

关 键 词：中医证候 动物模型 构建 评价 心气虚证 肝郁证 脾气虚证 肺气虚证 肾阳虚证 

分 类 号：R285.5[医药卫生—中药学]