主观症状动物模型研发的思考  

Thoughts on the Development of Animal Models for Subjective Symptoms

作　　者：潘志强[1] PAN Zhiqiang(School of Traditional Chinese Medicine,Shanghai University of Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中医学院,上海201203

出　　处：《南京中医药大学学报》2025年第1期19-25,共7页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82374307)。

摘　　要：主观症状的发生机制及新药研发有赖于实验动物模型。纵观目前常见的主观症状动物模型,以疼痛、失眠、瘙痒、眼干等主观症状动物模型较为成熟且稳定,为新药研发做出突出贡献。然而,眩晕、烦躁、胸闷、痞满、腰酸、肢体麻木等主观症状动物模型未见报道。基于此,简要概述了部分主观症状动物模型制备现状,并提出主观症状动物模型制备方法及评价指标的建议,以加大该领域的探索力度。The mechanism of subjective symptoms and the development of innovative drugs depend on experimental animal models.Reviewing animal models with common subjective symptoms,the animal models of subjective symptoms such as pain,insomnia,itching and dry eyes are relatively mature and stable,making outstanding contributions to the research and development of innovative drugs.However,animal models of subjective symptoms such as vertigo,irritability,chest tightness,fullness,backache and limb numbness have not been reported.Based on this,this paper briefly summarizes the current situation of the preparation of some subjective symptom animal models.Finally,some suggestions on the preparation methods and evaluation indexes of subjective symptom animal models are put forward,in order to increase the exploration efforts in this field.

关 键 词：主观症状 疾病模型 证候模型 动物模型 疼痛 失眠 瘙痒 眼干 

分 类 号：R285.5[医药卫生—中药学]