Biomechanical Study of Different Scaffold Designs for Reconstructing a Traumatic Distal Femur Defect Using Patient-Specific Computational Modeling  

作　　者：Hsien-Tsung Lu Ching-Chi Hsu Qi-Quan Jian Wei-Ting Chen 

机构地区：[1]Department of Orthopedics,School of Medicine,College of Medicine,Taipei Medical University,Taipei,11031,Taiwan [2]Department of Orthopedics,Taipei Medical University Hospital,Taipei,11031,Taiwan [3]Department of Mechanical Engineering,National Taiwan University of Science and Technology,Taipei,10607,Taiwan [4]Graduate Institute of Applied Science and Technology,National TaiwanUniversity of Science and Technology,Taipei,10607,Taiwan

出　　处：《Computer Modeling in Engineering & Sciences》2025年第2期1883-1898,共16页工程与科学中的计算机建模(英文)

基　　金：funded by the TaipeiMedical University-National Taiwan University of Science and Technology joint research program under Grant No.TMU-NTUST-109-09.

摘　　要：Reconstruction of a traumatic distal femur defect remains a therapeutic challenge.Bone defect implants have been proposed to substitute the bone defect,and their biomechanical performances can be analyzed via a numerical approach.However,the material assumptions for past computational human femur simulations were mainly homogeneous.Thus,this study aimed to design and analyze scaffolds for reconstructing the distal femur defect using a patient-specific finite element modeling technique.A three-dimensional finite element model of the human femur with accurate geometry and material distribution was developed using the finite element method and material mapping technique.An intact femur and a distal femur defect model treated with nine microstructure scaffolds and two solid scaffolds were investigated and compared under a single-leg stance loading.The results showed that the metal solid scaffold design could provide the most stable fixation for reconstructing the distal femur defect.However,the fixation stability was affected by various microstructure designs and pillar diameters.A microstructure scaffold can be designed to satisfy all the biomechanical indexes,opening up future possibilities for more stable reconstructions.A three-dimensional finite element model of the femur with real bone geometry and bone material distribution can be developed,and this patient-specific femur model can be used for studying other femoral fractures or injuries,paving the way for more comprehensive research in the field.Besides,this patient-specific finite element modeling technique can also be applied to developing other human or animal bone models,expanding the scope of biomechanical research.

关 键 词：Patient-specific modeling distal femur bone defect microstructure design finite element analysis 

分 类 号：R31[医药卫生—基础医学]