病原体蛋白糖基化与感染的基础与应用研究  

Basic and applied research on glycosylation and infection of pathogen proteins

作　　者：叶以琳 刘瑞杰 张瑜芯 张绍兴 林谦阁 孙桂芹[1] Ye Yilin;Liu Ruijie;Zhang Yuxin;Zhang Shaoxing;Lin Qiange;Sun Guiqin(School of Medical Technology and Information Engineering,Zhejiang Chinese Medical University,Hangzhou 310053)

机构地区：[1]浙江中医药大学医学技术与信息工程学院,杭州310053

出　　处：《中国抗生素杂志》2024年第12期1349-1359,F0002,共12页Chinese Journal of Antibiotics

摘　　要：糖基化是蛋白质的重要翻译后修饰之一,蛋白质糖基化在许多病原体感染的过程中发挥关键作用。在病毒中,糖基化作用参与病毒与宿主的识别、进入,影响病毒的复制和感染性。在细菌中,糖基化在鞭毛蛋白和菌毛蛋白的形成中发挥重要作用,并且对于细菌黏附、定植、感染性和免疫逃逸至关重要。本文总结了感染中病原体蛋白质糖基化作用及机制的相关研究,对中药糖类药物在抗感染治疗方面的应用进行了阐述,为病原体蛋白糖基化与感染的基础研究提供思路,为治疗感染性疾病糖类药物的开发奠定基础。Glycosylation is a crucial post-translational modification of proteins,playing a pivotal role in the infection caused by various pathogens.In viruses,glycosylation is involved in the recognition and entry processes between viruses and hosts,influencing viral replication and infectivity.Similarly,bacteria rely on glycosylation for the formation of flagellin and fimbrial proteins,which are essential for bacterial adhesion,colonization,infection,and immune evasion.This review provided a comprehensive summary of relevant studies elucidating the role and mechanism of pathogen protein glycosylation in infection.It offered valuable insights for further basic research on pathogen protein glycosylation and infection while laying a solid foundation for the development of carbohydratebased drugs to combat infectious diseases.

关 键 词：蛋白质糖基化 感染 机制 糖类药物 治疗 

分 类 号：R37[医药卫生—病原生物学]