百令片治疗结缔组织病相关间质性肺病的临床疗效  

Clinical Efficacy of Bailing Tablet in Treating Interstitial Lung Disease Associated with Connective Tissue Disease

作　　者：魏钊汝 孙英[2] 徐晓晨 赵国静 王坤[2] 胡海波 陆学超 WEI Zhaoru;SUN Ying;XU Xiaochen;ZHAO Guojing;WANG Kun;HU Haibo;LU Xuechao(The First Clinical College of Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250013,China;Qingdao Haici Hospital Affiliated to Qingdao University(Qingdao Hospital of Traditional Chinese Medicine),Qingdao 266033,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250013 [2]青岛大学附属青岛市海慈医院(青岛市中医医院),山东青岛266033

出　　处：《中国现代应用药学》2024年第23期3304-3309,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：山东省中医药科技项目(2020Q074);青岛市2018-2019年度中医药科研项目(2019-zyy001)。

摘　　要：目的观察百令片治疗结缔组织病相关间质性肺病(connective tissue disease-related interstitial lung disease,CTDILD)的疗效及对患者细胞因子及T-淋巴细胞亚群的影响,探讨其作用机制。方法将80例CTD-ILD患者随机分为对照组、治疗组。对照组(n=40)患者予西医常规治疗,治疗组(n=40)在对照组基础上加百令片口服,疗程3个月。主要观察指标为中医证候积分、哮喘控制问卷(asthma control questionnaire,ACQ)评分、总体疗效评分、六分钟步行距离及T淋巴细胞亚群(CD4^(+)%、CD8^(+)%、CD4^(+)/CD8^(+)T细胞比值)、细胞因子(IL-4、IL-10、IFN-γ、TNF-α)水平。结果治疗后,治疗组ACQ评分、中医证候积分比对照组有明显下降(P<0.05),总体有效率及六分钟步行距离显著高于对照组(P<0.05)。治疗组患者CD4^(+)%、CD8^(+)%及IL-4、TNF-α比对照组下降更明显(P<0.05),CD4^(+)/CD8^(+)T细胞比值、IFN-γ、IL-10水平均较治疗前增高,且较对照组增高更显著(P<0.05)。治疗前、后2组患者各安全性指标均未见明显异常,无不良事件。结论百令片辅助治疗CTD-ILD患者疗效确切,可显著改善临床症状,有助于患者心肺功能的恢复,调节T-淋巴细胞亚群及相关细胞因子,减轻炎症反应,抑制肺纤维化进展。OBJECTIVE To explore the treatment effect of Bailing tablet on patients with connective tissue disease associated interstitial lung disease(CTD-ILD)and its effects on cytokines and T-lymphocyte subsets of patients,and explore its possible mechanism.METHODS Eighty cases of CTD-ILD patients were randomly divided into control and treatment group.Patients in control group(n=40)were treated with regular treatment,and on the basis of the control group,patients in treatment group(n=40)were treated with Bailing tablets for 3 months.The main outcome measures were the traditional Chinese medicine(TCM)syndrome score,asthma control questionnaire(ACQ)score,overall efficacy,6-minute walking distance(6MWD),T-lymphocyte subsets(CD4^(+)%,CD8^(+)%,CD4^(+)/CD8^(+)T cell ratio),and cytokines(IL-4,IL-10,IFN-γ,TNF-α)levels.RESULTS After treatment,the ACQ and TCM score in treatment group were lower than those in control group(P<0.05),the overall efficacy and 6MWD in treatment group were higher than those in control group(P<0.05).CD4^(+)%,CD8^(+)%,IL-4 and TNF-α in treatment group were lower than those in control group(P<0.05).The ratio of CD4^(+)/CD8^(+)and the levels of IFN-γ and IL-10 in the treatment group were significant higher than those before treatment,and the increase was more than those in the control group(P<0.05).There were no significant abnormalities in safety indexes and no adverse events in the 2 groups before and after treatment.CONCLUSION Bailing tablet is effective in the adjuvant treatment of CTD-ILD patients,which can significantly improve clinical symptoms,contribute to the recovery of patients’cardiopulmonary function,regulate T-lymphocyte subpopulation and related cytokines,reduce inflammatory response,and inhibit the progression of pulmonary fibrosis.

关 键 词：结缔组织病相关间质性肺病 百令片 T-淋巴细胞亚群 细胞因子 

分 类 号：R969.3[医药卫生—药理学]