中医基于微生物-肠-脑轴治疗偏头痛的研究进展  

Research Progress of Traditional Chinese Medicine Treatment of Migraine Based on Microbial-intestinalbrain Axis

作　　者：安文凤 刘源香[2] AN Wenfeng;LIU Yuanxiang(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,济南250014 [2]山东中医药大学附属医院,济南250014

出　　处：《中国现代应用药学》2024年第23期3341-3346,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：河南省重点研发专项(221111310500)。

摘　　要：偏头痛是一种慢性神经血管性疾病,其发病机制尚不明确,目前比较认可的有三叉神经血管学说、皮质扩散抑制学说等。脑-肠轴是肠道微生物参与大脑与肠道双向信息交流的通路,可影响偏头痛的发作。偏头痛在中医学中属于“脑风”“头痛”的范畴,中医治疗偏头痛安全有效,不良反应小。近几年,越来越多研究提示偏头痛与微生物-肠-脑轴有一定联系,中药、针刺、艾灸等可以通过影响脑-肠肽水平、肠道菌群多样性和丰度等干预偏头痛发病机制以达到镇痛效果。因此,脑-肠肽、肠道菌群的改变可能是中医治疗偏头痛的潜在机制。文章结合最新研究成果,基于微生物-肠-脑轴理论综述偏头痛的发病机制及中医学对偏头痛患者微生物-肠-脑轴通路的影响,为科学研究偏头痛及临床诊治提供参考。Migraine is a chronic neurovascular disease,and its pathogenesis is still unclear.At present,trigeminal neurovascular theory and cortical spreading depression are relatively recognized.Brain-gut axis is a pathway for intestinal microorganisms to participate in two-way information exchange between brain and intestine,which can affect the attack of migraine.Migraine belongs to the category of"Brain wind"and"Headache"in traditional Chinese medicine,which is safe and effective in treating migraine with minimal adverse reactions.In recent years,more and more studies have suggested that migraine has a certain relationship with microbial-intestinal-brain axis.Traditional Chinese medicine,acupuncture and moxibustion can interfere with the pathogenesis of migraine by affecting the level of brain-gut peptide and the diversity and abundance of intestinal flora to achieve analgesic effect.Therefore,the changes of brain-gut peptide and intestinal flora may be the potential mechanism of traditional Chinese medicine in treating migraine.Based on the latest research results,this paper based on the theory of microbial-intestinal-brain axis,summarizes the pathogenesis of migraine and the influence of traditional Chinese medicine on the microbial-intestinal-brain axis pathway of migraine patients,so as to provide reference for scientific research and clinical diagnosis and treatment of migraine.

关 键 词：偏头痛 微生物-肠-脑轴 中医治疗 

分 类 号：R285.5[医药卫生—中药学]