成体海马神经发生障碍在抑郁症中的作用及其信号通路  

Role and Signaling Pathways of Adult Hippocampal Neurogenesis Disorders in Depression

作　　者：王婷婷 李萍[1] 郭海鹏 刘洋[1] 邹蔓姝 王宇红[1,2] WANG Tingting;LI Ping;GUO Haipeng;LIU Yang;ZOU Manshu;WANG Yuhong(Technology Innovation Center,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Key Laboratory of Traditional Chinese Medicine Prevention&Treatment of Depressive Disease,Changsha 410208,China)

机构地区：[1]湖南中医药大学科技创新中心,长沙410208 [2]抑郁类疾病中医药防治湖南省重点实验室,长沙410208

出　　处：《中国现代应用药学》2024年第22期3210-3218,共9页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(82174357);湖南省科药联合基金项目(2023JJ60476);湖南省中药粉体与创新药物研究省部共建国家重点实验室培育基地开放基金项目(2022FTKFJJ12);湖南省中医药管理局科研课题(B2023141);湖南中医药大学研究生创新课题(2024CX077)。

摘　　要：抑郁症作为一种严重威胁人类健康的精神疾病,具有发病率高、隐匿性强、易复发和难治愈等诸多特点。其潜在生物学机制尚不清楚,但分子和信号通路的异常会导致抑郁症。分子信号通路是一种进化上保守的多方面通路,可以控制不同的细胞进程。故深入研究抑郁症的生物学机制,为其预防和治疗提供潜在靶点,这对抗抑郁药物的研发具有显著的临床意义。海马是人体调节情绪和认知功能的关键脑区,成体海马神经发生障碍被认为与抑郁症的发生密切相关。神经发育信号如Wnt、Shh、Notch、BMP和Noggin等通路在调节成体海马神经发生的微环境中发挥重要作用。通过查阅相关文献,本文综述了上述通路与成体海马神经发生障碍的相关性在抑郁症中的研究进展,为抗抑郁靶点的发现和药物的研发提供新的思路。As a serious threat to human health,depression has many characteristics,such as high incidence,hidden,easy to relapse and difficult to cure.The underlying biological mechanism is unknown,but abnormalities in molecular and signaling pathways can lead to depression.Molecular signaling pathway is an evolutionarily conserved multifaceted pathway that can control different cellular processes.Therefore,an in-depth study of the biological mechanism of depression provides potential targets for its prevention and treatment,which has significant clinical significance in the development of anti-depression drugs.The hippocampus is a key brain region in regulating emotion and cognitive function.Neurogenetic disorders of the hippocampus in adults are thought to be closely related to the occurrence of depression.Neurodevelopmental signaling pathways such as Wnt,Shh,Notch,BMP,and Noggin play an important role in regulating the microenvironment of adult hippocampal neurogenesis.By reviewing relevant literature,this paper reviewed the research progress of the correlation between the above pathways and adult hippocamphal neurogenesis disorders in depression,providing new ideas for the discovery of anti-depression targets and drug development.

关 键 词：抑郁症 WNT通路 Shh通路 NOTCH通路 BMP通路 成体海马神经发生 

分 类 号：R966[医药卫生—药理学]