纳米药物在抗菌声动力疗法中的研究进展  

Research Progress of Nanomedicine in Antibacterial Sonodynamic Therapy

作　　者：杜林龙 张潇 李广宝 贝阮婷 庞鑫 DU Linlong;ZHANG Xiao;LI Guangbao;BEI Ruanting;PANG Xin(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450003,China)

机构地区：[1]河南中医药大学药学院,郑州450003

出　　处：《中国现代应用药学》2024年第22期3219-3226,共8页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(82274114);中华中医药学会青年人才托举工程项目(2022-QNRC2-A04)。

摘　　要：细菌感染,尤其是多重耐药菌诱发的感染,是威胁全球健康的重要隐患。声动力疗法是一种新兴的抗菌手段,主要利用低频超声波激活声敏感因子(即声敏剂),促使其产生活性氧分子以杀伤细菌。它具有广谱抗菌活性,不易诱发抗性,对多种耐药菌均有效。然而,声敏剂水溶性差,活性氧产量有限,细菌靶向性低等缺陷极大地限制了抗菌声动力疗法的临床应用。纳米技术在改善药物性质、靶向递送、多功能化方面独具优势,将其引入抗菌声动力疗法,可有效克服现有应用限制。鉴于此,本文综述了纳米药物在抗菌声动力疗法中的最新研究进展,并探讨其作用机制和优势,以为后续研究提供参考。Bacterial infections,especially those induced by multi drug resistant bacteria,are an important hidden danger threatening global health.Sonodynamic therapy is an emerging antibacterial mean that mainly utilizes low-frequency ultrasound to activate sonosensitizers,prompting their production of reactive oxygen molecules to kill bacteria.It has broad-spectrum antibacterial activity,does not easily induce resistance,and is effective against many drug-resistant bacteria.However,the poor water solubility,limited production of reactive oxygen species,and poor targeting of bacteria by sonosensitizers have greatly limited the clinical application of antibacterial sonodynamic therapy.Nanotechnology has many advantages in improving drug properties,targeted delivery and versatility,which can be introduced into antibacterial sonodynamic therapy to effectively overcome the existing limitations.In view of this,this article reviews the recent research progress of nanomedicines in antibacterial sonodynamic therapy and explores their mechanisms of action and advantages to provide references for subsequent research.

关 键 词：纳米药物 声动力疗法 抗菌 活性氧 

分 类 号：R978.1[医药卫生—药品]