沉默信息调节因子1抗动脉粥样硬化机制的研究进展  

Research Progress on the Mechanism of Silent Information Regulator 1 Against Atherosclerosis

作　　者：卓小琦 潘兴寿[2] ZHUO Xiaoqi;PAN Xingshou(Graduate School,Youjiang Medical University for Nationalities,Baise 533000,China;Cardiovascular Department,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院研究生学院,广西壮族自治区百色市533000 [2]右江民族医学院附属医院心血管内科,广西壮族自治区百色市533000

出　　处：《实用心脑肺血管病杂志》2025年第3期26-30,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：广西自然科学基金资助项目(2019JJA140159)。

摘　　要：沉默信息调节因子1(SIRT1)是一种关键的去乙酰化酶,具有调控细胞代谢、凋亡和自噬等生物学功能。动脉粥样硬化(AS)是多种疾病的病变基础,严重危害人类健康。本文通过回顾相关文献,总结了SIRT1抗AS的机制,包括激活SIRT1/叉头框转录因子O(FoxO)信号通路、抑制SIRT1/核因子-κB(NF-κB)/NOD样受体热蛋白结构域相关蛋白3(NLRP3)信号通路、激活单磷酸腺苷激活的蛋白激酶(AMPK)/SIRT1信号通路、促进巨噬细胞自噬与自我更新、调节内皮细胞脂质代谢、抑制促炎因子的表达、参与miRNA对内皮细胞和平滑肌细胞的调控,并指出SIRT1抗AS的确切机制仍需进一步深入研究。Silencing information regulatory factor 1(SIRT1)is a key deacetylase that has biological functions such as regulating cell metabolism,apoptosis,and autophagy.Atherosclerosis(AS)is the pathological basis of many diseases,which seriously endangers human health.By reviewing relevant literature,this paper summarized the mechanism of SIRT1 against AS,including activating SIRT1/forkhead transcription factor O(FoxO)signaling pathway,inhibiting SIRT1/nuclear factor-κB(NF-κB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,activating AMP-activated protein kinase(AMPK)/SIRT1 signaling pathway,promoting autophagy and self-renewal of macrophages,regulating lipid metabolism of endothelial cells,inhibiting the expression of pro-inflammatory factors,and participating in the regulation of endothelial cells and smooth muscle cells by miRNA,and pointed out that the exact mechanism of SIRT1 against AS needs further study.

关 键 词：动脉粥样硬化 沉默信息调节因子1 综述 

分 类 号：R543.5[医药卫生—心血管疾病]