2型糖尿病患者血糖控制差时的血脂异常类型与强化降糖治疗后血脂的变化  

The types of dyslipidemia with poor blood glucose control in type 2 diabetes mellitus patients and their changes after intensive hypoglycemic therapy

作　　者：杨丽惠 汤正义[2] 史燕青 李丽娟[1] 白梦瑶 孙立昊[2] YANG Lihui;TANG Zhengyi;SHI Yanqing(Department of Endocrinology,Ruijin Hospital Wuxi Branch Shanghai Jiao Tong University of Medicine,Wuxi 214000,China)

机构地区：[1]上海交通大学医学院附属瑞金医院无锡分院内分泌科,无锡214000 [2]上海交通大学医学院附属瑞金医院内分泌科

出　　处：《中国糖尿病杂志》2024年第12期903-906,共4页Chinese Journal of Diabetes

摘　　要：目的探讨T2DM患者血糖控制差时的血脂异常类型与在强化降糖治疗后血脂的变化。方法选取2022年8月至2023年7月于上海交通大学医学院附属瑞金医院无锡分院内分泌科住院治疗的T2DM患者140例,根据入组前治疗方式分为未使用药物治疗组(Con,n=50)、口服降糖药物治疗组(OAD,n=41)、Ins治疗组(Ins,n=49)。结果OAD、Ins组年龄、DM病程高于Con组(P<0.05),Ins组HOMA-IR、FC-P低于OAD组(P<0.05)。与治疗前比较,各组治疗后FPG、TC、TG、LDL-C、果糖胺降低,FC-P升高(P<0.05)。Pearson相关分析显示,Con、Ins组治疗后TG变化与△果糖胺呈正相关(P<0.05)。结论T2DM患者血糖控制不佳时TC、TG、LDL-C升高,强化降糖治疗后TC、TG、LDL-C降低,治疗后TG变化与△果糖胺呈正相关。Objective To investigate the types of dyslipidemia with poor blood glucose control in patients with type 2 diabetes mellitus(T2DM)and their changes after intensive hypoglycemic therapy.Methods A total of 140 T2DM patients who were hospitalized in the Endocrinology Department of Ruijin Hospital Wuxi Branch Shanghai Jiao Tong University of Medicine were enrolled in this study from August 2022 to July 2023.All the participants were divided into no therapy(Con,n=50),oral medication therapy(OAD,n=41),and insulin therapy group(Ins,n=49).Results The age and DM duration were higher in OAD and Ins groups than in Con group(P<0.05).HOMA-IR and FC-P were lower in Ins group than in OAD group(P<0.05).Compared with baseline,FPG,TC,TG,LDL-C,and fructosamine decreased and FC-P increased after treatment in each group(P<0.05).Pearson correlation analysis showed that the changes in TG after treatment in the Con and Ins groups were positively correlated with△fructosamine(P<0.05).Conclusions TC,TG,and LDL-C are increased when blood glucose control is poor in T2DM patients.After intensified hypoglycemic treatment,TC,TG,and LDL-C are decreased.The change in TG after treatment is positively correlated with△fructosamine.

关 键 词：糖尿病 2型 果糖胺 甘油三酯 总胆固醇 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 

分 类 号：R587.1[医药卫生—内分泌]