基于网络药理学探讨五加减正气散治疗病毒性肠炎的作用机制  

Study on the Mechanism of Five Modified Prescriptions of Zhengqi Powder in the Treatment of Rotavirus Enteritis Based on Network Pharmacology

作　　者：汪霞 WANG Xia(Department of Pharmacy,Shangrao People's Hospital,Jiangxi Province,Shangrao 334000,China)

机构地区：[1]上饶市人民医院药学部,江西上饶334000

出　　处：《中国中医药现代远程教育》2025年第3期102-104,共3页Chinese Medicine Modern Distance Education of China

摘　　要：目的 运用网络药理学探索五加减正气散治疗轮状病毒性肠炎(RE)的作用机制。方法 通过中药系统药理学数据库与分析平台(TCMSP)、SymMap数据库收集五加减正气散有效化合物,筛选出有效化合物并进行靶点预测;在GeneCards数据库获取RE相关疾病作用靶点;通过Venny 2.1.0软件获取五加减正气散治疗RE的有效靶点并构建蛋白互作网络(PPI);采用Cytoscape 3.8.2软件构建“药物-成分-靶点”网络,然后对网络模块靶点进行基因本体论(GO)富集和京都基因与基因组百科全书(KEGG)通路分析。结果 五加减正气散中筛选得到有效化合物63个,得到靶点812个,其中作用于RE的靶点41个。KEGG富集分析表明核心靶点主要作用于炎症性肠病(IBD)、Toll样受体信号通路、肿瘤坏死因子(TNF)信号通路。结论五加减正气散可通过调节免疫系统和炎症信号通路达到治疗目的。Objective To explore the mechanism of five modified prescriptions of Zhengqi powder in the treatment of rotavirus enteritis(RE)based on network pharmacology.Methods The effective compounds were collected through TCM System Pharmacology Database and Analysis Platform(TCMSP)and SymMap database,and the effective compounds were screened and the target was predicted.Re-related disease targets were obtained from GeneCards database.The effective target of five modified prescriptions of Zhengqi powder for RE treatment was obtained by Venny 2.1.0 software and the protein interaction network(PPI)was constructed.The"drug-compose-target"network was constructed using Cytoscape 3.8.2 software,followed by gene ontology(CO)enrichment and Kyoto Encyclopedia of Genes and Cenomes(KECC)pathway analysis for the network module targets.Results 63 effective compounds and 812 targets were screened,including 4l targets for rotavirus enteritis.KEGG enrichment analysis showed that the core targets mainly act on the inflam-matory bowel disease(IBD),Toll-like receptor signaling pathway,and TNF signaling pathway.Conclusion Five modified prescriptions ofZhengqi powder achieve therapeutic goals mainly by regulating the immune system and inflammatory signaling Pathways.

关 键 词：轮状病毒性肠炎 五加减正气散 网络药理学 作用机制 

分 类 号：R285[医药卫生—中药学]