象山县成人25羟维生素D水平及其与骨转换标志物和骨密度的相关性分析  

Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults

作　　者：鲍红丹 周雅芬 史琼瑶 郭婧怡 章振林 高超 BAO Hongdan;ZHOU Yafen;SHI Qiongyao;GUO Jingyi;ZHANG Zhenlin;GAO Chao(Department of Endocrinology,Ningbo Fourth People's Hospital,Ningbo,Zhejiang 315700,China;不详)

机构地区：[1]宁波市第四医院内分泌科,浙江宁波315700 [2]上海交通大学医学院附属第六人民医院临床研究中心,上海200233 [3]上海交通大学医学院附属第六人民医院骨质疏松和骨病专科上海市骨疾病临床研究中心,上海200233

出　　处：《中华全科医学》2025年第1期36-39,共4页Chinese Journal of General Practice

基　　金：国家自然科学基金青年基金项目(81900808)。

摘　　要：目的了解宁波市象山县成人25羟维生素D[25(OH)D]水平和缺乏情况,分析25(OH)D水平与骨转换标志物(BTMs)、骨密度(BMD)的关系。方法2020年8—11月招募来自宁波市象山县的志愿者3117例,其中男性1122例,女性1995例,年龄为22~95岁。采集研究对象血清样本进行25(OH)D、BTMs检测,采用双能X线吸收仪测定研究对象的腰椎、股骨颈及全髋部BMD。结果研究人群25(OH)D不足比例为39.7%(1236/3117),25(OH)D缺乏比例为9.1%(284/3117)。按年龄分组后,在小于50岁人群中,男女25(OH)D缺乏比例均最高,分别为11.1%(21/189)和31.0%(139/449)。按性别分组后,25(OH)D水平与Ⅰ型胶原羧基端肽β特殊序列(β-CTX)水平均呈负相关关系(男性:r=-0.161,P<0.001;女性:r=-0.069,P=0.002)。男性25(OH)D水平与股骨颈BMD(β=0.001,P=0.019)、全髋部BMD(β=0.001,P=0.034)呈正相关关系。结论宁波市农村地区25(OH)D缺乏和不足仍较为普遍,尤其是<50岁的女性,需引起重视,并及早调整生活方式或使用维生素D补充剂。此外,本研究发现人群中25(OH)D水平与BMD呈正相关关系,与β-CTX呈负相关关系。Objective To investigate the level and deficiency of 25-hydroxyvitamin D[25(OH)D]in adults living in Xiangshan County,Ningbo City,and to analyze the association between 25(OH)D levels with bone turnover markers(BTMs)and bone mineral density(BMD).Methods From August to November 2020,3117 volunteers were recruited from Xiangshan County,Ningbo City,including 1122 males and 1995 females,with an age range of 22-95 years old.Serum samples were collected for 25(OH)D and BTMs detection.BMD of the lumbar spine,femoral neck,and total hip of the subjects were measured by dual-energy X-ray absorptiometry.Results The proportion of 25(OH)D insufficiency and deficiency in the study population was 39.7%(1236/3117)and 9.1%(284/3117),respectively.After grouping by age,the proportion of 25(OH)D deficiency was highest in men and women under 50 years of age,with 11.1%(21/189)and 31.0%(139/449),respectively.After grouping by gender,25(OH)D levels were negatively associated with special sequenceβcarboxyterminal peptide of collagenⅠ(β-CTX)levels in men and women(male:r=-0.161,P<0.001;female:r=-0.069,P=0.002).In addition,25(OH)D levels were positively associated with femoral neck BMD(β=0.001,P=0.019)and total hip BMD(β=0.001,P=0.034)in men.Conclusion 25(OH)D deficiency and insufficiency are still common in rural areas of Ningbo City,especially among women younger than 50 years old.The results suggest that these people need to pay more attention to their 25(OH)D levels and adjust their lifestyle or use vitamin D supplements early.In addition,25(OH)D levels were found to be positively associated with BMD and negatively associated withβ-CTX levels in this study population.

关 键 词：25羟维生素D 骨转换标志物 骨密度 

分 类 号：R591.44[医药卫生—内科学] R68[医药卫生—临床医学]