巴曲酶联合利多卡因静脉滴注对伴耳鸣的平坦型突发性耳聋的临床疗效研究  

Clinical efficacy of batroxase combined with lidocaine intravenous infusion in the treatment of flat sudden deafness with tinnitus

作　　者：李泓磊 陈曦[1] 汪永宽 杨飞[1] Li Honglei;Chen Xi;Wang Yongkuan;Yang Fei(Department of Otolaryngology,Head and Neck Surgery,Deyang People′s Hospital,Sichuan 618000,China)

机构地区：[1]四川省德阳市人民医院耳鼻咽喉头颈外科,618000

出　　处：《山西医药杂志》2025年第1期8-11,共4页Shanxi Medical Journal

基　　金：四川省老年学学会研究项目(24SCLN086)。

摘　　要：目的探究巴曲酶与利多卡因联合应用于伴耳鸣的平坦型突发性耳聋中的临床疗效。方法选取我院2021年1月至2024年1月间收治的90例伴耳鸣平坦型突发性耳聋患者,随机分为A组、B组和对照组,每组各30例。其中对照组予以甲泼尼龙联合银杏叶提取物治疗,B组在对照组的基础上予以巴曲酶治疗,A组在对照组的基础上予以巴曲酶联合利多卡因静脉滴注治疗。观察3组患者治疗后的临床疗效、听力提高值,比较治疗前后耳鸣严重程度[耳鸣残疾评估表(THI)]和血清纤维蛋白原水平。结果3组患者临床疗效总有效率上比较差异无统计学意义(P>0.05);A、B组患者相较对照组患者在低、中、高频段的听力提高值上更高(P<0.05),且A组听力提高值高于B组,差异具有统计学意义(P<0.05);对照组治疗前后THI评分上比较差异无统计学意义(P>0.05),A、B组患者治疗后相较治疗前的THI评分上更低,差异有统计学意义(P<0.05),与对照组相比,A、B组THI评分更低,且A组低于B组,差异有统计学意义(P<0.05);3组患者治疗后相较治疗前血清纤维蛋白原水平下降(P<0.05),A、B组相较对照组在血清纤维蛋白原水平上更低,且A组上述指标低于B组,差异有统计学意义(P<0.05)。结论巴曲酶联合利多卡因滴注治疗伴耳鸣的平坦型突发性耳聋患者者可减轻患者耳鸣症状,有效提高患者听力,降低血清纤维蛋白原水平,此联合疗法疗效尚可,值得临床推广应用。Objective To investigate the clinical efficacy of the combination of bacitracin and lidocaine in flat-type sudden deafness with tinnitus.Methods A total of 90 cases with flat-type sudden deafness and tinnitus admitted to our hospital between January 2021 and January 2024 were randomly divided into group A,group B,and control group,with 30 cases in each group.The control group was treated with methylprednisolone combined with ginkgo biloba extract,group B was treated with Bactrim on the basis of the control group,and group A was treated with Bactrim combined with lidocaine intravenous drip on the basis of the control group.The clinical efficacy and hearing improvement values of the three groups were observed,and the severity of tinnitus[Tinnitus Handicap Index(THI)]and serum fibrinogen levels were compared before and after treatment.Results There was no statistically significant difference in the total effective rate of clinical efficacy among the three groups(P>0.05).Patients in groups A and B had higher hearing improvement values in the low,middle and high frequency bands compared with patients in the control group(P<0.05),and the hearing improvement value of group A was higher than that of group B,with a statistically significant difference(P<0.05).There was no statistically significant difference between the THI scores in the control group before and after the treatment(P>0.05).The THI scores of patients in groups A and B were lower after treatment compared with those before treatment,and the difference was statistically significant(P<0.05),the THI scores of patients in groups A and B were lower compared with those in control group,and group A was lower than that of group B,and the difference was statistically significant(P<0.05).The serum fibrinogen levels of the patients in the three groups decreased after treatment compared with those before treatment(P<0.05),and groups A and B had higher hearing improvement values than those in the control group,and the difference was statistically significant(P<0.05).The

关 键 词：听力丧失 突发性 巴曲酶 利多卡因 耳鸣症状 临床疗效 

分 类 号：R76[医药卫生—耳鼻咽喉科]