Self-adhesive ultrasound-mediated triboelectric nanogenerator device for subcutaneous antibacterial treatment and accelerated wound healing  

自粘式超声波驱动摩擦电纳米发电机用于皮下抗菌和促进伤口愈合

作　　者：Xiaowei Lv Chunmei Guo Sihan Luo Lina Qi Jingyi Shi Jianhang Zhao Ying Chen Aijun He Quli Fan 吕晓薇;郭春梅;罗思晗;齐丽娜;石静怡;赵建航;陈莹;何爱军;范曲立(Key Laboratory for Organic Electronics&Information Displays and Institute of Advanced Materials,Nanjing University of Post&Telecommunications,Nanjing 210021,China;School of Electronic Science and Engineering,Nanjing University,Nanjing 210023,China)

机构地区：[1]Key Laboratory for Organic Electronics&Information Displays and Institute of Advanced Materials,Nanjing University of Post&Telecommunications,Nanjing 210021,China [2]School of Electronic Science and Engineering,Nanjing University,Nanjing 210023,China

出　　处：《Science China Materials》2025年第1期261-269,共9页中国科学(材料科学)(英文版)

基　　金：Fundamental Research Funds of the National Natural Science Foundation of China (32071724,52373142)。

摘　　要：Electrical stimulation therapy has excellent potential for wound healing and tissue regeneration.However,conventional approaches often require external power sources and implantable electrodes,which can limit their practical applications.Herein,we report the development of an ultrasound-mediated powered wound healing device(LH-TENG)that employs skin-adhesive AgC@L-g-PAM/HPC hydrogel as electrodes instead of traditional ones.Under ultrasound excitation,the LH-TENG can firmly adhere to tissue surfaces and generate a uniform electric field around the wound area,promoting cell migration,proliferation,and accelerating healing.Notably,the device exhibits antibacterial properties,making it promising for treating infected chronic wounds.Due to its wireless power supply,simple structure,and excellent biocompatibility,this ultrasound-mediated wound healing device has the potential and advantages of developing implantable therapy devices for treating infected chronic wounds.电刺激疗法在伤口愈合和组织再生方面具有巨大潜力.然而,传统方法通常需要外部电源和可植入电极,这可能限制它们的实际应用.在此,我们报道了一种超声介导的自供电伤口愈合装置(LH-TENG)的开发,该装置采用皮肤粘附性AgC@L-g-PAM/HPC水凝胶作为电极,在超声介导下, LH-TENG能牢固附着在组织表面,并在伤口区域周围产生均匀的电场,促进细胞迁移、增殖并加速愈合.此外,该装置表现出抗菌特性,因此其在治疗感染的慢性伤口方面具有潜力.

关 键 词：ultrasound mediation triboelectric nanogenerator antibacterial wound healing 

分 类 号：R318[医药卫生—生物医学工程] TM31[医药卫生—基础医学]