Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease  

作　　者：Wen-Tao Sun Jian-Yong Du Jia Wang Yi-Long Wang Er-Dan Dong 

机构地区：[1]Research Center for Cardiopulmonary Rehabilitation,University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital),Schoolof Health and Life Sciences,Universityof Health and Rehabilitation Sciences,Qingdao 266071,China [2]Department of Cardiology and Instituteof Vascular Medicine,Peking University Third Hospital,TheInstituteofCardiovascular Sciences,Peking University,State Key Laboratoryof Vascular Homeostasisand Remodeling,Peking University,Beijing 100191,China

出　　处：《Science China(Life Sciences)》2025年第1期158-175,共18页中国科学(生命科学英文版)

基　　金：supported by the National Natural Science Foundation of China(82200440 to Sun,W.,T.);Shandong Provincial Natural Science Foundation(ZR2022QH234 to Sun,W.,T.);Open Research Project in State Key Laboratory of Vascular Homeostasis and Remodeling(Peking University)(202406 to Sun,W.,T.&202405 to Du,J.,Y.);Taishan Scholar Young Talent Program(tsqn202312241 to Sun,W.,T.);CAMS Innovation Fund for Medical Sciences(2021-I2M-5-003 to Dong,E.,D.);Haihe Laboratory of Cell Ecosystem Innovation Fund(HH22KYZX0047 to Dong,E.,D.);National Natural Science Foundation of China(82200278 to Du,J.,Y.&92268105 to Wang,J.).

摘　　要：Cardiac rehabilitation,a comprehensive exercise-based lifestyle and medical management,is effective in decreasing morbidity and improving life quality in patients with coronary heart disease.Endothelial function,an irreplaceable indicator in coronary heart disease progression,is measured by various methods in traditional cardiac rehabilitation pathways,including medicinal treatment,aerobic training,and smoking cessation.Nevertheless,studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are limited.This article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways,including exercise training,lifestyle modification and psychological intervention in patients with coronary heart disease,and related experimental models,and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial function.In exercise training and some lifestyle interventions,the enhanced bioavailability of nitric oxide,increased circulating endothelial progenitor cells(EPCs),and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart disease.Moreover,the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play roles.On the one hand,to develop more endothelium-protective rehabilitation methods in coronary heart disease,adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment methods.On the other hand,additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

关 键 词：cardiac rehabilitation coronary heart disease endothelial function 

分 类 号：R541.4[医药卫生—心血管疾病] R493[医药卫生—内科学]