多肽水凝胶在药物缓释或控释中的应用研究进展  

Progress on the application of polypeptide hydrogels in drug sustained/controlled release

作　　者：方雪榕 邹慧儒 Fang Xuerong;Zou Huiru(Deapartment of Central Laboratory,Tianjin Stomatological Hospital,School of Medicine,Nankai University&Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin300041,China)

机构地区：[1]天津市口腔医院中心实验室,南开大学医学院,天津市口腔功能重建重点实验室,天津300041

出　　处：《中华口腔医学杂志》2025年第1期94-100,共7页Chinese Journal of Stomatology

基　　金：天津市科技计划(22JCYBJC01240, 23JCYBJC01490);天津市卫生健康科技项目(TJWJ2024XK017)

摘　　要：多肽水凝胶凭借其良好的生物相容性、可降解性以及较低的细胞毒性,近年在生物医学领域备受关注;其能模拟细胞外基质微环境,有效包封药物并实现药物的缓释或控释,进而促进组织再生。本文介绍多肽水凝胶在药物缓释或控释中的应用研究进展,全面梳理多肽的选择与设计原则、多肽浓度的优化策略以及水凝胶的构建技术等方面研究热点,阐述多肽水凝胶实现药物缓释或控释的原理与机制,总结适用于不同缓释或控释体系的检测手段,并对多肽水凝胶在药物递送领域的未来发展前景进行展望,以期为后续深入研究提供参考。In recent years,peptide hydrogels have garnered significant attention in the biomedical field due to their excellent biocompatibility,biodegradability,and low cytotoxicity.They can mimic the microenvironment of the extracellular matrix,effectively encapsulate drugs,and achieve sustained or controlled drug release,thereby facilitate tissue regeneration.This article introduces the research progress in the application of peptide hydrogels for drug sustained/controlled release.It summarizes the research hotspots in the selection and design principles of peptides,optimization strategies for peptide concentrations,and hydrogel construction techniques.Furthermore,the principles and mechanisms underlying the sustained/controlled drug release from polypeptide hydrogels are elucidated,and the detection methods applicable to different sustained/controlled release systems are summarized.The article also prospects the application potential of peptide hydrogels in the field of drug delivery and offers insights for subsequent in-depth research.

关 键 词：水凝胶类 肽类 药物释放系统 多肽水凝胶 缓释 控释 

分 类 号：R943[医药卫生—药剂学]