不同剂型亮丙瑞林治疗中枢性性早熟女童的疗效观察  

Efficacy of different dosage forms of leuprorelin in central precocious puberty girls

作　　者：冯跃英 方洁 干冬梅 FENG Yue-ying;FANG Jie;GAN Dong-mei(Department of Pediatrics,Women and Children's Hospital of Ningbo University,Ningbo,Zhejiang 315012,China)

机构地区：[1]宁波大学附属妇女儿童医院儿科,浙江宁波315012

出　　处：《中国妇幼保健》2025年第2期235-238,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划项目(2023KY290);浙江省宁波市医学重点学科建设计划项目(2022-B17)。

摘　　要：目的探讨3个月及1个月剂型亮丙瑞林对中枢性性早熟(CPP)女童的治疗效果。方法对60例CPP女童接受促性腺激素释放激素类似物(GnRHa)治疗患者随机分组,3M组(30例):接受3WH月剂型的亮丙瑞林针(11.25 mg),每12周注射1次;1M组(30例):接受1个月剂型的亮丙瑞林针(3.75 mg),每4周注射1次;随访1年,比较两组黄体生成素(LH)、卵泡刺激素(FSH)、子宫、卵巢容积及生长速度及骨龄改变,并记录相关不良反应。结果两组比较:①LH峰值(IU/L):初诊时分别为16.20±14.58及13.75±9.66,12个月复查时分别为2.02±0.81及1.74±0.63;②FSH峰值(IU/L):初诊时分别为18.81±9.22及15.37±5.49,12个月复查时分别为4.17±1.23及3.58±1.12;③骨龄指数(骨龄/年龄):初诊时分别为1.20±0.09及1.19±0.08,12个月复查时分别为1.16±0.07及1.15±0.07;④卵巢容积(ml):初诊时分别为3.60±1.24及3.20±1.34,12个月复查时分别为2.03±0.65及2.07±0.69;以上两组比较差异均无统计学意义(均P>0.05),提示3个月剂型能很好抑制性激素水平,控制性腺发育,并控制骨龄进展,与1个月剂型疗效无明显差别。结论3个月剂型与1个月剂型亮丙瑞林对CPP女童具有相同的抑制效果,值得推广。Objective To investigate the therapeutic effect of 3-month and 1-month depot leuprorelin on girls with central precocious puberty.Methods Sixty girls with central precocious puberty(CPP)were randomly divided into two groups:3M group(30 cases):accepted 3-month depot leuprorelin(11.25 mg)every 12 weeks,and 1M group(30 cases):received 1-month depot leuprorelin(3.75 mg)every 4 weeks.After 1 year of follow-up,the changes of luteinizing hormone(LH),follicle-stimulating hormone(FSH),uterine and ovarian volume,growth rate and bone age were compared between the two groups,and the related adverse reactions were recorded.Results Comparison of the two groups:①peak LH(IU/L):16.20±14.58 and 13.75±9.66 at initial diagnosis,2.02±0.81 and 1.74±0.63 at 12 months follow-up,respectively.②Peak FSH(IU/L):18.81±9.22 and 15.37±5.49 at initial diagnosis,and 4.17±1.23 and 3.58±1.12 at 12 months follow-up,respectively.③Bone age index(bone age/chronological age):1.20±0.09 and 1.19±0.08 at initial diagnosis,1.16±0.07 and 1.15±0.07 at 12 months follow-up,respectively.④Ovarian volume(ml):3.60±1.24 and 3.20±1.34 at initial diagnosis,and 2.03±0.65 and 2.07±0.69 at 12 months follow-up,respectively.There were no significant differences between the all above two groups(all P>0.05).It was suggested that the 3-month depot leuprorelin could well inhibit the level of sex hormones,control gonadal development,and control the progression of bone age,and there was no significant difference in efficacy from the 1-month depot leuprorelin.

关 键 词：中枢性性早熟 亮丙瑞林 疗效 

分 类 号：R725.8[医药卫生—儿科]