EDA-complexes-enabled photochemical synthesis of α-amino acids with imines and tetrabutylammonium oxalate  

作　　者：Min-Hang Zhou Jun Jiang Wei-Min He 

机构地区：[1]School of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China

出　　处：《Chinese Chemical Letters》2025年第1期1-2,共2页中国化学快报(英文版)

摘　　要：The synthesis ofα-amino acid from imines with different carbonyl sources is attractive for both synthetic organic and medicinal chemistry communities.Imines,which were easily available from the corresponding ketones and amines,were employed as one of the most ideal precursors.Traditionally,cyanation and subsequent hydrolysis were required to install the carboxyl group^([1]).In these cases,the toxicity of the cyanation reagents limited its further synthetic applications in organic chemsitry.Besides,metal activation of imine substrates to make the organometallic intermediate and trap CO_(2) to give the desiredα-amino acid were also developed by many groups(Scheme 1A).The utilization of stoiochiometric amounts of metal reagents was required to realize the transformation.Recently,Yu reported a novel photocatalytic reductive carboxylation protocol for synthesis ofα-amino acid from imines with CO_(2)as the carbonyl source^([2]).

关 键 词：synthesis CARBONYL PHOTOCHEMICAL 

分 类 号：O62[理学—有机化学]