Metal-free construction of diverse 1,2,4-triazolo[1,5-a]pyridines on water  

作　　者：Chunhua Ma Mengjiao Liu Siyu Ouyang Zhenwei Cui Jingjing Bi Yuqin Jiang Zhiguo Zhang 

机构地区：[1]Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals,Key Laboratory of Green Chemical Media and Reactions,Ministry of Education,Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical,Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China [2]Chongqing Aoshe Bio-chemical Co.Ltd.,Chongqing 400000,China

出　　处：《Chinese Chemical Letters》2025年第1期244-247,共4页中国化学快报(英文版)

基　　金：financial support from the National Natural Science Foundation of China(No.82003585);the Program for Science&Technology Innovation Talents in Universities of Henan Province(No.24HASTIT069);the Technical Innovation Team of Henan Normal University(No.2022TD03);the Special Project for Fundamental Research in University of Henan Province(No.23ZX009);the Henan Science and Technology Program(No.232102310364);the Key Project of Henan Educational Committee(No.22A150041);Excellent Youth Foundation of Henan Scientific Committee(No.222300420012);the Young Core Instructor Training Program of Xinyang Agriculture and Forestry University(2023)。

摘　　要：A transition-metal-and oxidant-free amination/cyclization reaction to access 1,2,4-triazolo[1,5-a]pyridines was realized in water by using amino diphenylphosphinate as amino source.A broad array of readily accessible N-(pyridyl)amides could be converted into the products featuring a diverse set of functional groups.The sustainable methodology was successfully applied to the late-stage functionalization of natural products and drugs.

关 键 词：1 2 4-Triazolo[1 5-a]pyridines On water N-(Pyridyl)amides CYCLIZATION METAL-FREE 

分 类 号：O62[理学—有机化学]