A nanocomposite film with layer-by-layer self-assembled gold nanospheres driven by cucurbit[7]uril for the selective transport of l-tryptophan and lysozyme  

作　　者：Hao Zhang Haonan Qu Ehsan Bahojb Noruzi Haibing Li Feng Liang 

机构地区：[1]The State Key Laboratory of Refractories and Metallurgy,School of Chemistry and Chemical Engineering,Wuhan University of Science and Technology,Wuhan 430081,China [2]National Key Laboratory of Green Pesticide,College of Chemistry,Central China Normal University,Wuhan 430079,China [3]School of Environmental and Chemical Engineering,Jiangsu Ocean University,Lianyungang 222005,China

出　　处：《Chinese Chemical Letters》2025年第1期258-261,共4页中国化学快报(英文版)

基　　金：financially supported by National Natural Science Foundation of China(Nos.22371086,22071074,21772055);the National Key Research and Development Program(No.2021YFA0716702);the 111 Project(No.B17019);the China Postdoctoral Science Foundation(No.2020 M672388);Self-determined research funds of CCNU from the colleges’basic research and operation of MOE,National Natural Science Foundation of China(No.22006055);the State Key Laboratory of Environmental Chemistry and Ecotoxicology,RCEES,CAS(No.KF2017-4)。

摘　　要：Selective separation of amino acids and proteins is crucial in various areas of research,including proteomics,protein structure and function studies,protein purification and drug development,and biosensing and biodetection.A nanocomposite film is formed by combining layer-by-layer self-assembled gold nanospheres(Au NPs)driven by cucurbit[7]uril(CB[7])and polymethyl methacrylate(PMMA)film.Due to the host-guest interactions,the selective transmission of l-tryptophan in the nanocomposite film is confirmed by the current-voltage measurements using a picoammeter.Furthermore,by adjusting the particle size of Au NPs to increase channel size,lysozyme containing multiple tryptophan residues can selectively pass through the nanocomposite film,indicating the high versatility and adaptability of the nanocomposite film.This study will provide a new direction for the selective separation of amino acids and proteins.

关 键 词：Nanocomposite film uril Gold nanospheres Host-guest interactions Selective transmission 

分 类 号：TQ028.8[化学工程] TQ936