I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations  

作　　者：You Zhou Li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang Zhi-Cheng Yu Xing Li Yan-Dong Wu Kai-Lu Zheng An-Xin Wu 

机构地区：[1]National Key Laboratory of Green Pesticide,International Joint Research Center for Intelligent Biosensor Technology and Health,College of Chemistry,Central China Normal University,Wuhan 430079,China [2]Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs,The First Dongguan Affiliated Hospital,School of Pharmacy,Guangdong Medical University,Dongguan 523808,China [3]State Key Laboratory of Chemical Biology and Drug Discovery,Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hong Kong SAR 999077,China

出　　处：《Chinese Chemical Letters》2025年第1期277-282,共6页中国化学快报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.21971080,22171098);supported by Chengdu Guibao Science&Technology Co.,Ltd.This work was also supported by the 111 Project(No.B17019)。

摘　　要：The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction conditions.The key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one pot.Moreover,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关 键 词：Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission 

分 类 号：O62[理学—有机化学]