茯神木中三萜类化学成分研究  

Chemical constituents of triterpenes in Pini Radix in Poria

作　　者：杨财子 邓子怡 孙云鹏 王国凯 郁阳 刘劲松 YANG Cai-zi;DENG Zi-yi;SUN Yun-peng;WANG Guo-kai;YU Yang;LIU Jin-song(College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012;Key Laboratory for Functional Substances of Chinese Medicine and Natural Medicine,Hefei 230012;Functional Activity and Resource Utilization of Edible and Medicinal Fungi,Joint Laboratory of Anhui Province,Hefei 230012)

机构地区：[1]安徽中医药大学药学院,合肥230012 [2]中药功效物质校级重点实验室,合肥230012 [3]食药用菌功能活性与资源利用安徽省联合共建学科重点实验室,合肥230012

出　　处：《中南药学》2025年第1期66-72,共7页Central South Pharmacy

基　　金：国家中医药管理局高水平中医药重点学科中药化学学科开放课题(No.HKDCCM2024011)。

摘　　要：目的研究茯神木中三萜类化学成分。方法运用硅胶柱色谱、RP-18中压柱色谱、Sephadex LH-20葡聚糖凝胶、半制备HPLC等分离手段进行分离纯化,所获得的单体化合物经核磁共振波谱和质谱数据鉴定。结果从茯神木中分离鉴定出16个单体化合物,分别为齿孔酸(1)、栓菌酸(2)、松苓新酸(3)、脱氢齿孔酸(4)、茯苓酸(5)、去氢茯苓酸(6)、猪苓酸(7)、茯苓新酸AM(8)、茯苓新酸DM(9)、3β,-16α-二羟基羊毛甾-7,9(11),24-三烯-21-酸(10)、16α-羟基松苓新酸(11)、茯苓新酸B(12)、去氢土莫酸(13)、茯苓新酸A(14)、茯苓新酸BM(15)、茯苓新酸G(16)。结论以上16个化合物皆为首次从茯神木中分离鉴定。Objective To determine the chemical constituents of triterpenes in Pini Radix in Poria.Methods Triterpenes were separated and purified with chromatographic techniques such as silica gel column,RP-18 medium pressure column,Sephadex LH-20 column,and preparative HPLC,and identified by NMR and MS spectroscopy.Results Totally 16 triterpenes were isolated from Pini Radix in Poria,and identified as eburicoic acid(1),trametenolic acid(2),dehydrotrametenolic acid(3),dehydroeburicoic acid(4),pachymic acid(5),dehydropachymic acid(6),polyporenic acid(7),poricoic acid AM(8),poricoic acid DM(9),3β,-16α-dihydroxylanosta-7,9(11),24-trien-21-oic acid(10),16α-hydroxytrametenolic acid(11),poricoic acid B(12),dehydrotumulosic acid(13),poricoic acid A(14),poricoic acid BM(15),and poricoic acid G(16).Conclusion All the 16 compounds have been obtained from the Pini Radix in Poria for the first time.

关 键 词：茯神木 化学成分 结构鉴定 三萜类化合物 

分 类 号：R283[医药卫生—中药学] R284[医药卫生—中医学]