高海拔缺氧对降糖药体内代谢的影响研究进展  

Research progress in the effect of high-altitude hypoxia on the metabolism of hypoglycemic drugs in vivo

作　　者：桓芝兰 王鸽 许贵琴 吴雪 王亚峰[2] HUAN Zhi-lan;WANG Ge;XU Gui-qin;WU Xue;WANG Ya-feng(Department of Pharmacy,Qinghai Provincial University,Xining 810001;Qinghai Provincial People’s Hospital,Xining 810000)

机构地区：[1]青海大学药学系,西宁810001 [2]青海省人民医院,西宁810000

出　　处：《中南药学》2025年第1期203-207,共5页Central South Pharmacy

基　　金：2021年昆仑英才·高端创新培养领军人才。

摘　　要：高海拔缺氧环境影响机体对众多药物的处置过程,通过改变药物的药动学参数进而影响药效。影响药动学参数的因素包括药物代谢酶、药物转运体和肠道菌群等,还可通过一些相关因子、核受体及相关网络信号通路来调控药物代谢酶和药物转运体而间接改变药动学参数。本文总结了高海拔缺氧下降糖药的药动学参数变化的研究进展,并探讨了引起此种变化的因素及作用机制。High-altitude hypoxic environment may affect the body’s disposal of numerous drugs,change pharmacokinetic parameters,and affect drug efficacy.The factors that affect pharmacokinetic parameters include drug metabolic enzymes,drug transporters,and gut microbiota,which may be indirectly altered by regulating drug metabolic enzymes and drug transporters through related factors,nuclear receptors,and network signaling pathways.This article summarized the research progress in the changes in pharmacokinetic parameters of glucose lowering drugs under high-altitude hypoxia,and explored the factors and mechanism of such changes.

关 键 词：高海拔缺氧 降糖药 药动学 药物代谢酶 药物转运体 肠道菌群 

分 类 号：R96[医药卫生—药理学]