基于NHANES数据库的相对脂肪质量指数与成年人胆结石关系的大样本横断面研究  

A large sample cross-sectional study of the relationship between relative fat mass index and gallstones in adults based on the NHANES database

作　　者：盛臻芳 王兆祥 钟绍 唐枫燕 SHENG Zhenfang;WANG Zhaoxiang;ZHONG Shao;TANG Fengyan(Department of General Surgery,the Fifth People′s Hospital of Kunshan in Jiangsu Province,Suzhou,Jiangsu,215300;Department of Endocrinology,the First People's Hospital of Kunshan in Jiangsu Province,Suzhou,Jiangsu,215300)

机构地区：[1]江苏省昆山市第五人民医院普外科,江苏苏州215300 [2]江苏省昆山市第一人民医院内分泌科,江苏苏州215300

出　　处：《实用临床医药杂志》2025年第2期108-113,118,共7页Journal of Clinical Medicine in Practice

基　　金：江苏省昆山市重点研发计划项目(KS2201)。

摘　　要：目的分析相对脂肪质量指数(RFM)与成年人胆结石风险之间的关联。方法纳入参与美国国家健康与营养调查(NHANES)的成年受试者。通过受试者身高和腰围计算RFM。通过受试者的自我报告获取其胆结石疾病史。受试者RFM与胆结石风险之间的关系分析采用Logistic回归分析、平滑曲线拟合以及亚组分析。结果本研究共纳入4874名受试者。胆结石受试者的RFM水平高于非胆结石受试者,差异有统计学意义(P<0.001)。调整各种混杂因素后,RFM水平与胆结石风险独立相关(OR=1.095,95%CI:1.022~1.173,P=0.010)。平滑曲线拟合分析表明,随着受试者的RFM水平升高,其胆结石患病风险呈上升趋势。亚组分析结果显示,RFM与胆结石的关系在不同人群中不存在显著差异。结论较高的RFM水平与受试者胆结石风险增加相关。RFM或可作为一种经济、有效且简便的胆结石风险评估指标,但尚需进一步的前瞻性研究加以验证。Objective To analyze the association between relative fat mass index(RFM)and the risk of gallstones in adults.Methods Adult participants from the National Health and Nutrition Examination Survey(NHANES)were included.RFM was calculated based on the participants′height and waist circumference.The history of gallstone disease was obtained through self-reports.The relationship between RFM and the risk of gallstones was assessed using Logistic regression analysis,smooth curve fitting and subgroup analysis.Results A total of 4,874 participants were included in the study.The RFM level of gallstone subjects was significantly higher than that of non-gallstone subjects(P<0.001).After adjusting for various confounders,RFM level was found to be independently associated with the risk of gallstones(OR=1.095,95%CI:1.022 to 1.173,P=0.010).Smooth curve fitting analysis indicated that the risk of gallstone disease also increased as RFM levels increased.The results of subgroup analysis showed no significant differences in the relationship between RFM and gallstones across different populations.Conclusion Higher RFM level is associated with an increased risk of gallstones in participants.RFM may serve as an economical,effective and convenient indicator for assessing the risk of gallstones,but further prospective studies are required to validate these findings.

关 键 词：肥胖 相对脂肪质量 胆结石 成年人群 横断面研究 

分 类 号：R857.11[医药卫生—航空、航天与航海医学] R575.6[医药卫生—临床医学] R319