术前雄激素注射对尿道下裂并阴茎发育不良患儿的应用效果  

Application Effect of Preoperative Intramuscular Injection of Androgen on Children with Hypospadias and Penile Dysplasia

作　　者：花鸣春[1] 闫秀兰[1] 邵家松[1] HUA Mingchun;YAN Xiulan;SHAO Jiasong(Department of Pediatric Surgery,Medical Cosmetic Surgery,the Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi,China)

机构地区：[1]桂林医学院附属医院小儿外科、医学美容外科,广西桂林541001

出　　处：《中国药物滥用防治杂志》2024年第12期2269-2270,共2页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：广西教育厅中青年教师基础能力提升项目(编号:KY2016YB325)。

摘　　要：目的:研究术前雄激素肌肉注射对小儿尿道下裂并阴茎发育不良患儿局部血管微环境及手术成功率的影响。方法:选择本院2022年2月—2024年2月收治的80例小儿尿道下裂并阴茎发育不良患儿为研究对象,均实施尿道成形术,对照组(n=40)术前不应用雄激素,研究组(n=40)术前肌肉注射雄激素,对比两组局部血管微环境、手术成功率及阴茎发育情况。结果:研究组治疗后VEGF、CD31、手术成功率及阴茎长度、冠状沟周径高于对照组,且并发症发生率低于对照组(P<0.05)。结论:术前肌肉注射雄激素,能调节尿道下裂并阴茎发育不良患儿局部血管微环境,提高手术成功率。Objective:To study the effect of preoperative intramuscular injection of androgen on the local vascular microenvironment and the success rate of surgery in pediatric children with hypospadias and penile dysplasia.Methods:A total of 80 children with hypospadias and penile dysplasia admitted to our hospital from February 2022 to February 2024 were selected as the research objects,and all of them underwent urethroplasty.The control group(n=40)did not use androgen before operation,and the study group(n=40)received preoperative intramuscular injection of androgen.The local vascular microenvironment,success rate of operation and penile development were compared between the two groups.Results:After treatment,VEGF,CD31,surgical success rate,penile length and coronal sulcus circumference in the study group were higher than those in the control group,and the incidence of complications was lower than that of the control group(P<0.05).Conclusion:Preoperative intramuscular injection of androgen can regulate the local vascular microenvironment in children with hypospadias and peniledysplasia and improve the success rate of surgery.

关 键 词：尿道下裂 阴茎发育不良 雄激素 血管微环境 手术成功率 

分 类 号：R69[医药卫生—泌尿科学]