益生菌在妇产科疾病中的应用及其作用机制的研究进展  

Applications and mechanisms of probiotics in obstetric and gynecological diseases:advances in research

作　　者：崔倩[1] 许英慧 CUI Qian;XU Yinghui(School of European Language and Culture Studies,Dalian University of Foreign Languages,Dalian,Liaoning 116044,China;不详)

机构地区：[1]大连外国语大学欧洲语言学院,辽宁大连116044 [2]大连金普新区妇幼保健院

出　　处：《中国微生态学杂志》2024年第12期1474-1479,1484,共7页Chinese Journal of Microecology

摘　　要：益生菌在妇产科疾病应用中展现出巨大潜力,尤其是在调节阴道及肠道的菌群失调方面效果显著。阴道菌群和肠道菌群失调与多种妇产科疾病密切相关。在调节阴道菌群方面,益生菌通过抑制病原体过度生长、降低局部和全身炎症反应及增强免疫功能,达到有效恢复阴道菌群平衡的目的,从而增强治疗细菌性阴道病、宫颈病变和不孕症等疾病的疗效,降低其复发风险,改善妊娠结局。此外,益生菌通过调节肠道菌群来辅助治疗多囊卵巢综合征、妊娠期糖尿病、复发性流产和妇科肿瘤等疾病。本文通过系统梳理现有文献,综合分析了益生菌在妇产科疾病中的应用及其作用机制,以期为今后的研究及临床应用提供科学依据。Probiotics have demonstrated significant potential in obstetric and gynecological diseases,especially in regulating vaginal and gut microbiota imbalances.Imbalances in vaginal and gut microbiota are strongly linked to numerous obstetric and gynecological disorders.In terms of vaginal microbiota regulation,probiotics inhibit the overgrowth of pathogens,reduce both local and systemic inflammation,and enhance immune function.These mechanisms restore the balance of vaginal microbiota,improve treatment efficacy for bacterial vaginosis,cervical lesions and infertility,reduce recurrence risk,and enhance pregnancy outcomes.Additionally,probiotics play a potential auxiliary therapeutic role in conditions such as polycystic ovary syndrome,gestational diabetes,recurrent miscarriage and gynecological tumors through gut microbiota regulation.This review systematically summarized existing literature,analyzed the applications and mechanisms of probiotics in obstetric and gynecological diseases,in order to provide scientific evidences for future studies and clinical practices.

关 键 词：益生菌 妇产科疾病 阴道菌群 肠道菌群 微生态平衡 

分 类 号：Q939.93[生物学—微生物学]