早期补充维生素D对早产儿免疫球蛋白、T细胞亚群及血清白细胞介素-1β、白细胞介素-10水平的影响  

Effects of early vitamin D supplementation on immunoglobulin,T cell subsets,serum interleukin-1βand interleukin-10 levels in premature infants

作　　者：张睿[1] 孙越 李娜[3] Zhang Rui;Sun Yue;Li Na(Department of Neonatology,Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China;Department of Traditional Chinese Medicine Preparation,Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China;Department of Nursing,Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院新生儿科,沧州061000 [2]河北省沧州中西医结合医院中药制剂科,沧州061000 [3]河北省沧州中西医结合医院护理部,沧州061000

出　　处：《中国医师进修杂志》2025年第2期102-105,共4页Chinese Journal of Postgraduates of Medicine

基　　金：河北省卫生健康委科研基金项目(20232145)。

摘　　要：目的探讨早期补充维生素D对早产儿免疫功能的影响。方法前瞻性选择河北省沧州中西医结合医院2022年1月至2023年3月收治的150例早产儿为研究对象,按随机数字表法分为干预组和对照组,每组75例。对照组接受配方奶喂养,干预组在对照组基础上早期补充维生素D,疗程14 d。比较两组干预前后血清25-羟维生素D[25-(OH)D]、免疫球蛋白(Ig)、T细胞亚群、补体C3、C4及血清细胞因子白细胞介素(IL)-1β、IL-10水平。结果干预组干预后血清25-(OH)D水平高于对照组[(30.13±6.00)nmol/L比(26.84±5.79)nmol/L],IL-1β水平低于对照组[(0.54±0.20)ng/L比(0.65±0.23)ng/L],差异有统计学意义(P<0.05)。干预组干预后CD_(3)^(+)、CD_(4)^(+)、补体C3、C4及IL-10水平均高于对照组[0.692±0.043比0.632±0.038、0.400±0.027比0.369±0.026、(0.98±0.26)g/L比(0.84±0.24)g/L、(0.20±0.05)g/L比(0.16±0.04)g/L、(13.82±3.64)ng/L比(11.36±2.93)ng/L],差异有统计学意义(P<0.05)。两组干预前后IgA、IgM、IgG水平比较差异无统计学意义(P>0.05)。结论早期补充维生素D能明显改善早产儿T细胞亚群,调节IL-1β/IL-10水平。Objective To explore the effects of early vitamin D supplementation on the immune function of premature infants.Methods A total of 150 premature infants admitted to Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2023 were enrolled perspectively,they were divided into the intervention group(75 cases)and the control group(75 cases)by the random number table method.The control group received formula milk intervention,and the intervention group received early vitamin D supplementation treatment on the basis of the control group.The course of treatment was 14 d.The levels of serum 25-hydroxyvitamin D[25-(OH)D],immunoglobulin(Ig),T cell subsets,complement C3,C4,and serum interleukin(IL)-1βand IL-10 were compared between the two groups before and after intervention.Results The level of serum 25-(OH)D in the intervention group at 14 d after intervention was higher than that in the control group,the level of IL-1βwas lower than that in the control group:(30.13±6.00)nmol/L vs.(26.84±5.79)nmol/L,(0.54±0.20)ng/L vs.(0.65±0.23)ng/L,there were statistical differences(P<0.05).The levels of CD_(3)^(+),CD_(4)^(+),complement C3,C4,and IL-10 in the intervention group were higher than those in the control group at 14 d after intervention:0.692±0.043 vs.0.632±0.038,0.400±0.027 vs.0.369±0.026,(0.98±0.26)g/L vs.(0.84±0.24)g/L,(0.20±0.05)g/L vs.(0.16±0.04)g/L,(13.82±3.64)ng/L vs.(11.36±2.93)ng/L,there were statistical differences(P<0.05).There were no statistically significant differences in the levels of IgA,IgM and IgG between the two groups before and after intervention(P>0.05).Conclusions Early vitamin D supplementation can significantly improve T cell subsets and regulate IL-1β/IL-10 levels in premature infants.

关 键 词：婴儿 早产 维生素D 免疫球蛋白类 T淋巴细胞 白细胞介素类 

分 类 号：R72[医药卫生—儿科]