核因子κB、β连环素在尖锐湿疣皮损组织中的表达及其与临床预后的关系  

The expression of nuclear factor-κB andβ-catenin in skin lesions of condyloma acuminatum and their relationship with clinical prognosis

作　　者：刘雨琛 林立 王姗姗[2] 安月鹏[2] 杨素清[2] Liu Yuchen;Lin Li;Wang Shanshan;An Yuepeng;Yang Suqing(The First Clinical College of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Dermatology,the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学第一临床医学院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院皮肤科,哈尔滨150040

出　　处：《中国医师进修杂志》2025年第2期140-145,共6页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨核因子κB(NF-κB)、β连环素在尖锐湿疣皮损组织中表达情况,并分析其与临床预后的关系。方法前瞻性选取2020年12月至2023年6月黑龙江中医药大学附属第一医院收治的96例尖锐湿疣患者,将其作为病例组;另留取同期在医院接受外阴整形术或包皮环切术治疗的96例患者的正常组织样本,将其作为对照组。病例组接受5-氨基酮戊酸光动力疗法(ALA-PDT)治疗,根据治疗后6个月是否复发分为复发亚组与未复发亚组。比较不同组别患者NF-κB、β连环素表达;使用Phi系数分析NF-κB、β连环素与尖锐湿疣的相关性,采用COX回归分析检验NF-κB、β连环素与复发的关系,绘制受试者工作特征(ROC)曲线分析NF-κB、β连环素对尖锐湿疣患者复发的预测价值。结果病例组皮损组织中NF-κB、β连环素阳性率均高于对照组[55.21%(53/96)比23.96%(23/96)、56.25%(54/96)比36.46%(35/96)],差异有统计学意义(P<0.05)。经Phi系数检验显示,NF-κB、β连环素阳性与尖锐湿疣呈正相关关系(r>0,P<0.05)。随访6个月,96例患者中35例患者复发,复发率为36.46%(35/96),复发亚组皮损组织中NF-κB、β连环素阳性率明显高于未复发亚组[85.71%(30/35)比37.70%(23/61)、85.71%(30/35)比39.34%(24/61)],差异有统计学意义(P<0.05)。经COX回归分析检验显示NF-κB、β连环素阳性表达与尖锐湿疣患者治疗后复发有关(HR=4.017、3.898,95%CI 1.516~10.646、1.470~10.336,P<0.05)。绘制ROC曲线可见NF-κB、β连环素及二者联合均对尖锐湿疣患者治疗后复发存在中等预测价值,曲线下面积(AUC)分别为0.740、0.732,其中以联合预测价值最高,AUC为0.810(P<0.05)。结论尖锐湿疣患者皮损组织中NF-κB、β连环素阳性率较高,且对患者治疗后复发情况具有一定预测价值。Objective To explore the expression of nuclear factor-κB(NF-κB)andβ-catenin in skin lesions of condyloma acuminatum,and analyze their relationship with clinical prognosis.Methods A prospective study was conducted to select 96 patients with condyloma acuminatum admitted to the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from December 2020 to June 2023 as the case group.Another 96 normal tissue samples from patients who underwent external genital plastic surgery or circumcision at the same time in the hospital were taken as the control group.All patients in the case group received 5-aminolevulinic acid photodynamic therapy(ALA-PDT)treatment,and the outcome was achieved at 6 months after follow-up.The case group was divided into recurrent subgroups and non-recurrent subgroups based on whether there was a recurrence.The expression of NF-κB andβ-catenin in patients with different prognoses between the case group and the control group were compared.The Phi coefficient was used to analyze the correlation between NF-κB,β-catenin,and condyloma acuminatum.COX regression analysis were used to test the relationship between NF-κB,β-catenin and recurrence,and then receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of NF-κB,β-catenin for recurrence in patients with condyloma acuminatum.Results The positive rates of NF-κB andβ-catenin in the lesion tissues of the case group were higher than those in the control group:55.21%(53/96)vs.23.96%(23/96),56.25%(54/96)vs.36.46%(35/96),and there were statistical differences(P<0.05).According to the Phi coefficient test,there was a positive correlation between NF-κB andβ-catenin positivity and condyloma acuminatum(r>0,P<0.05).After 6 months of follow-up,35 of the 96 patients relapsed,with a recurrence rate of 36.46%(35/96).The positive rates of NF-κB andβ-catenin in the recurrent subgroup were significantly higher than those in the non-recurrent subgroup:85.71%(30/35)vs.37.70%(23/61),85.71%(30/35)v

关 键 词：尖锐湿疣 核因子ΚB受体活化因子 Β连环素 预后 相关性 

分 类 号：R75[医药卫生—皮肤病学与性病学]