低分子量肝素钠注射液联合硫酸镁注射液和拉贝洛尔片治疗重度妊娠期高血压综合征的效果观察  

Effect of low-molecular-weight heparin sodium injection combined with magnesium sulfate injection and labetalol tablets in the treatment of severe pregnancy induced hypertension syndrome

作　　者：付昕[1] 刘爱敏[1] Fu Xin;Liu Aimin(Department of Obstetrics and Gynecology,Anyang Maternal and Child Health Hospital,Anyang 455000,China)

机构地区：[1]安阳市妇幼保健院产科,安阳455000

出　　处：《中国实用医刊》2024年第24期85-89,共5页Chinese Journal of Practical Medicine

摘　　要：目的观察低分子量肝素钠注射液联合硫酸镁注射液和拉贝洛尔片治疗重度妊娠期高血压综合征(PIH)的效果。方法队列研究。抽取2019年1月至2022年12月安阳市妇幼保健院收治的重度PIH患者78例, 按随机数字表法分为对照组和研究组, 每组39例。对照组采用硫酸镁注射液和拉贝洛尔片治疗, 研究组在对照组基础上采用低分子量肝素钠注射液治疗。比较两组治疗效果、血压水平[舒张压(DBP)、收缩压(SBP)]、凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)]、肾功能[血尿素氮(BUN)、血清肌酐(Scr)、24 h尿蛋白]及母婴不良事件发生率。结果研究组总有效率(94.87%, 37/39)高于对照组(71.79%, 28/39), P<0.05。治疗后, 研究组DBP、SBP水平低于对照组(P<0.05)。治疗后, 研究组PT、APTT水平高于对照组, FIB、D-D水平低于对照组(P<0.05)。治疗后, 研究组BUN、Scr、24 h尿蛋白水平低于对照组(P<0.05)。研究组母婴不良事件发生率(5.13%, 2/39)低于对照组(23.08%, 9/39), P<0.05。结论低分子量肝素钠注射液联合硫酸镁注射液和拉贝洛尔片治疗重度PIH的效果显著, 能降低患者血压, 改善机体凝血功能和肾功能, 减少母婴不良事件的发生。Objective To observe the efficacy of low-molecular-weight heparin sodium injection combined with magnesium sulfate injection and labetalol tablets in the treatment of severe pregnancy induced hypertension syndrome(PIH).MethodsA total of 78 patients with severe PIH treated in Anyang Maternal and Child Health Hospital from January 2019 to December 2022 were selected for the cohort study,and they were divided into the control group and the study group by random number table method,with 39 cases in each group.The control group was treated with magnesium sulfate injection and labetalol tablets,while the study group was treated with low-molecular-weight heparin sodium injection based the treatment of the control group.The treatment efficacy of blood pressure,including diastolic pressure(DBP)and systolic pressure(SBP),the coagulation function,including prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and D-dimer(D-D),renal function evaluated by blood urea nitrogen(BUN),serum creatinine(Scr)and 24 h urine protein,and incidence of maternal and neonatal adverse events were compared between the two groups.ResultsThe total effective rate of the stydy group was 94.87%(37/39),higher than the 71.79%(28/39)of the control group(P<0.05).After treatment,the DBP and SBP levels in the stydy group were lower than those in the control group(P<0.05).After treatment,the PT and APTT levels in the stydy group were higher than those in the control group,while the FIB and D-D levels were lower than those in the control group(P<0.05).After treatment,the levels of BUN,Scr and 24 h urine protein in the stydy group were lower than those in the control group(P<0.05).The incidence of maternal and infant adverse events in the stydy group was 5.13%(2/39),lower than the 23.08%(9/39)in the control group(P<0.05).ConclusionsLow-molecular-weight heparin sodium injection combined with magnesium sulfate injection and labetalol tablets has obvious effect in the treatment of severe PIH,which can reduce blood pressure,improve co

关 键 词：妊娠期高血压 低分子量肝素钠注射液 硫酸镁注射液 拉贝洛尔片 

分 类 号：R71[医药卫生—妇产科学]