美罗培南与亚胺培南西司他丁钠治疗重症肺炎的效果对比  

Comparison of effects of meropenem and imipenem cilastatin sodium in the treatment of severe pneumonia

作　　者：张宁霞 Zhang Ningxia(Department of Clinical Pharmacy,Zhoukou Central Hospital,Zhoukou 466000,China)

机构地区：[1]周口市中心医院临床药学科,周口466000

出　　处：《中国实用医刊》2024年第24期89-92,共4页Chinese Journal of Practical Medicine

摘　　要：目的对比美罗培南与亚胺培南西司他丁钠治疗重症肺炎的临床效果。方法回顾性抽取2021年12月至2024年1月周口市中心医院收治的重症肺炎患者94例, 按照治疗方案分为对照组(47例, 给予亚胺培南西司他丁治疗)和观察组(47例, 给予美罗培南治疗)。比较两组治疗效果、炎症指标、血气分析指标、肺功能指标、机体恢复情况及不良反应发生率。结果观察组总有效率(95.74%, 45/47)高于对照组(82.98%, 39/47), P<0.05。观察组C反应蛋白、白细胞计数、白细胞介素-6、降钙素原水平及二氧化碳分压均低于对照组(P均<0.05)。观察组动脉氧分压、血氧饱和度、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC均高于对照组(P均<0.05)。观察组发热消退时间、咳嗽消退时间、咳痰消退时间、肺部湿啰音消退时间、呼吸困难消退时间均短于对照组(P均<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论与亚胺培南西司他丁钠比较, 美罗培南治疗重症肺炎效果更好, 可增强疗效, 减轻炎症, 改善血气分析指标与肺功能, 促进身体康复, 且安全。Objective To compare the effects of meropenem and imipenem cilastatin sodium in the treatment of severe pneumonia.MethodsNinety-four patients with severe pneumonia admitted to Zhoukou Central Hospital from December 2021 to January 2024 were selected retrospectively,and they were divided into the control group(47 cases,treated with imipenem cilastatin sodium)and the observation group(47 cases,treated with meropenem)according to the treatment plan.The treatment effect,inflammation indexes,blood gas analysis indexes,lung function indexes,body recovery and incidence of adverse reactions were compared between the two groups.ResultsThe total effective rate of the observation group(95.74%,45/47)was higher than that of the control group(82.98%,39/47),P<0.05.The levels of C-reactive protein,white blood cell count,interleukin-6,procalcitonin,partial pressure of carbon dioxide of the observation group were lower than those of the control group(all P<0.05).The arterial partial pressure of oxygen,oxygen saturation,forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),FEV1/FVC in the observation group were higher than those in the control group(all P<0.05).The times of syndrome resolution,including fever,cough resolution time,sputum,pulmonary crackle and dyspnea,in the observation group were shorter than those in the control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).ConclusionsCompare with imipenem cilastatin sodium,meropenem has a better effect in the treatment of severe pneumonia;it can enhance the efficacy,reduce inflammation,improve blood gas analysis and lung function,and promote physical recovery,with high safety.

关 键 词：肺炎 美罗培南 亚胺培南西司他丁钠 炎症指标 

分 类 号：R47[医药卫生—护理学]