肠道菌群影响缺血再灌注损伤中程序性细胞死亡水平的研究进展  

Advances in the study of intestinal flora affecting the level of programmed cell death in ischemia reperfusion injury

作　　者：赵紫岑 冷玉芳[1,2] 常利娅 王玉 李东斌 邢阳 吴宇轩 Zhao Zicen;Leng Yufang;Chang Liya;Wang Yu;Li Dongbin;Xing Yang;Wu Yuxuan(First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Anesthesiology,the First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Clinical Medicine,Fenyang College of Shanxi Medical University,Fenyang 032200,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院麻醉科,兰州730000 [3]山西医科大学汾阳学院临床医学系,汾阳032200

出　　处：《国际麻醉学与复苏杂志》2024年第12期1335-1339,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(82260381)。

摘　　要：肠道菌群及其代谢物通过多种作用影响人体代谢,且在缺血再灌注损伤(IRI)过程中发挥作用。许多研究发现IRI涉及多种程序性细胞死亡(PCD)。文章总结肠道菌群及其代谢物对IRI相关PCD的影响,描述不同PCD的机制及当前研究中证实的肠道菌群及其代谢物在细胞、动物水平上作用于PCD的结果,为IRI相关PCD的进一步研究提供依据。The intestinal flora and its metabolites influence human metabolism in various ways and play a significant role in ischemia reperfusion injury(IRI).Numerous studies have shown that IRI is associated with multiple forms of programmed cell death(PCD).In this paper,we will summarize the effects of gut flora and its metabolites on IRI-related PCD,describe the mechanisms of different types of PCD,and review current studies that confirm the impact of gut flora and its metabolites on PCD at both cellular and animal levels.This review aims to pave the way for further research on IRI-related PCD in the future.

关 键 词：肠道微生物 程序性细胞死亡 :缺血再灌注损伤 

分 类 号：R28[医药卫生—中药学]