Rat models of frozen shoulder:Classification and evaluation  

作　　者：Hezirui Gu Wenqing Xie Hengzhen Li Shuguang Liu Yusheng Li 

机构地区：[1]Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,China [2]Xiangya School of Medicine,Central South University,Changsha,China [3]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,China [4]Department of Joint Surgery,Honghui Hospital,Xi'an Jiaotong University,Xi'an,China

出　　处：《Animal Models and Experimental Medicine》2025年第1期92-101,共10页动物模型与实验医学(英文)

基　　金：National Key R&D Program of China,Grant/Award Number:2021YFC2502100,2023YFC3603404 and 2019YFA0111900;The National Natural Science Foundation of China,Grant/Award Number:82072506,82272611 and 92268115;The Hunan Provincial Science Fund for Distinguished Young Scholars,Grant/Award Number:2024JJ2089;The Hunan Young Talents of Science and Technology,Grant/Award Number:2021RC3025;The Provincial Clinical Medical Technology Innovation Project of Hunan,Grant/Award Number:2023SK2024 and 2020SK53709;The Provincial Natural Science Foundation of Hunan,Grant/Award Number:2020JJ3060;The National Natural Science Foundation of Hunan Province,Grant/Award Number:2023JJ30949;The National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Grant/Award Number:2021KFJJ02 and 2021LNJJ05;The Hunan Provincial Innovation Foundation for Postgraduate,Grant/Award Number:CX20230308 and CX20230312;The Independent Exploration and Innovation Project for Postgraduate Students of Central South University,Grant/Award Number:2024ZZTS0163。

摘　　要：Frozen shoulder(FS),also known as adhesive capsulitis,is a condition that causes contraction and stiffness of the shoulder joint capsule.The main symptoms are per-sistent shoulder pain and a limited range of motion in all directions.These symp-toms and poor prognosis affect people's physical health and quality of life.Currently,the specific mechanisms of FS remain unclear,and there is variability in treatment methods and their efficacy.Additionally,the early symptoms of FS are difficult to distinguish from those of other shoulder diseases,complicating early diagnosis and treatment.Therefore,it is necessary to develop and utilize animal models to under-stand the pathogenesis of FS and to explore treatment strategies,providing insights into the prevention and treatment of human FS.This paper reviews the rat models available for FS research,including external immobilization models,surgical internal immobilization models,injection modeling models,and endocrine modeling models.It introduces the basic procedures for these models and compares and analyzes the advantages,disadvantages,and applicability of each modeling method.Finally,our paper summarizes the common methods for evaluating FS rat models.

关 键 词：endocrine modeling INJECTION rat model surgical internal immobilization 

分 类 号：R73[医药卫生—肿瘤]