大肠息肉患者病例特点和中医证型分布及其与焦虑抑郁的关系  

Study on Clinical Characteristics and Distribution of Traditional Chinese Medicine Syndrome Types in Patients with Colorectal Polyps and Their Relationship with Anxiety and Depression

作　　者：李志青 欧泽莹 古越鸣 梁民联 杨锦辉 马新蕾[1] LI Zhiqing;OU Zeying;GU Yueming;LIANG Minian;YANG Jinhui;MA Xinei(Dongguan Hospital,Guangzhou University of Chinese Medicine,Dongguan 523000 Guangdong,China)

机构地区：[1]广州中医药大学东莞医院,广东东莞523000

出　　处：《广州中医药大学学报》2025年第1期18-25,共8页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省基础与应用基础研究基金企业联合基金(公共卫生与医药健康领域)项目(编号:2022A1515220059)。

摘　　要：【目的】探讨大肠息肉患者的流行病学特征、中医证型分布及焦虑抑郁情况。【方法】选取2022年1月至2023年12月期间在广州中医药大学东莞医院内镜中心行结肠镜检查或治疗的大肠息肉患者200例(息肉组)和肠道未见异常者100例(非息肉组),收集2组患者的相关病历资料,对大肠息肉患者进行中医辨证分型,并对其流行病学特征包括性别、年龄、体质量指数(BMI)、烟酒史等进行问卷调查和记录,同时进行医院焦虑抑郁量表(HAD)评分,以评估其焦虑、抑郁状态。【结果】(1)流行病学特征方面,息肉组与非息肉组患者的性别、年龄、BMI、吸烟、饮酒等一般情况比较,差异均有统计学意义(P <0.05或P <0.01)。具体表现为,息肉组以男性为主(63.5%),而非息肉组以女性为主(58.0%),说明相比女性患者,男性患者更易患大肠息肉;年龄方面,息肉组以51~60岁年龄段为主(36.0%),非息肉组以41~50岁年龄段为主(38.0%),说明息肉组的平均年龄较非息肉组大;另外,息肉组的肥胖(BMI≥28.0 kg/m2)、吸烟、饮酒人数占比均较非息肉组高。(2)息肉情况方面,大肠息肉多发病于左半结肠,占息肉组的53.5%;腺瘤性息肉占所有息肉病理类型的57.0%;肠息肉大小以<1.0 cm为主,占所有息肉的81.5%;单发性肠息肉占45.5%,多发性肠息肉占54.5%,说明大肠息肉仍以多发为主。(3)中医证型分布方面,200例大肠息肉患者中,脾虚湿滞证93例(46.5%),大肠湿热证59例(29.5%),肝郁气滞证27例(13.5%),湿瘀阻滞证21例(10.5%)。不同性别、年龄、BMI和饮酒情况的大肠息肉患者中医证型分布比较,差异均无统计学意义(P> 0.05);而不同吸烟情况的大肠息肉患者中医证型分布比较,差异有统计学意义(P <0.05)。不同发病部位、息肉数目、病理类型的大肠息肉患者中医证型分布比较,差异均无统计学意义(P> 0.05);而不同息肉大小的大肠息肉患者中医证型分布比较,差�Objective To investigate the clinical characteristics,distribution of traditional Chinese medicine(TCM)syndrome types,and the anxiety and depression status in patients with colorectal polyps.Methods From January 2022 to December 2023,a total of 200 cases of patients with colorectal polyps(polyp group)and 100 patients without intestinal abnormalities(non-polyp group)under colonoscope who received colonoscopy or treatment at the Endoscopy Center of Dongguan Hospital,Guangzhou University of Chinese Medicine were enrolled.The relevant medical information of the patients in the two groups were collected,and then TCM syndrome differentiation of patients with colorectal polyps were carried out,the general infromation including gender,age,body mass index(BMI),smoking history and alcohol-intake history was recorded,and Hospital Anxiety and Depression Scale(HAD)score was calculated for assessing their anxiety and depression status.Results(1)The investigation of clinical characteristics showed that between the polyp group and the non-polyp group,the differences in the general information of gender,age,BMI,smoking history and alcohol-intake history were statistically significant(P<0.05 or P<0.01).As for the gender,the polyp group was predominated by the male(63.5%),while the non-polyp group was predominated by the female(58.0%),indicating that male patients were more likely to suffer from colorectal polyps.In terms of the age,the age group of 51-60 years old accounted for a higher percentage(36.0%)in the polyp group,while the age group of 41-50 years old accounted for a higher percentage(38.0%)in the non-polyp group,indicating that the polyp group had an elder average age than the non-polyp group.In addition,the percentages of patients with obesity(BMI≥28.0 kg/m2),smoking history,and alcohol-intake history in the polyp group were higher than those in the non-polyp group.(2)The analysis of features of colorectal polyps showed that the polyps were mostly seen in the left colon,accounting for 53.5%in the polyp group;adenomato

关 键 词：大肠息肉 病例特点 中医证型 脾虚湿滞证 大肠湿热证 焦虑抑郁 危险因素 

分 类 号：R269.569[医药卫生—中西医结合]