基于古今医案云平台挖掘中药治疗肝郁型多囊卵巢综合征的用药规律  

Data Mining of Medication Rules of Chinese Herbal Medicine in Treating Polycystic Ovary Syndrome of Liver Stagnation Type Based on Ancient and Modern Medical Record Cloud Platform

作　　者：陈淑莹 薛娟珍 王乃平[1] 赵春景[1] CHEN Shuying;XUE Juanzhen;WANG Naiping;ZHAO Chunjing(Dongguan Hospital of Guangzhou University of Chinese Medicine,Dongguan 523000 Guangdong,China)

机构地区：[1]广州中医药大学东莞医院,广东东莞523000

出　　处：《广州中医药大学学报》2025年第1期254-259,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20211408);东莞市高水平医院建设专项(编号:20231800903501)。

摘　　要：【目的】基于古今医案云平台探讨中药治疗肝郁型多囊卵巢综合征(PCOS)的用药规律。【方法】检索中国知网、维普、万方等数据库从建库至2013年12月所收录的中医药治疗肝郁型PCOS的医案,提取方药及证型数据,构建数据库,运用古今医案云平台(V2.3.7)进行肝郁证相关证型统计、中药频次统计、中药属性及功效分析、药物的关联分析与聚类分析,采用复杂网络分析挖掘其核心处方。【结果】共纳入医案处方108首,涉及药物174味,证型以肾虚肝郁为主,用药频次最高的是当归和柴胡;药物归经以归肝、脾、肾经为主,药物属性以气平、味甘最常见,药物功效以疏肝解郁为主。关联分析得到“当归-白芍”“柴胡-白芍”等17个药对;聚类分析得到4组中药聚类组合。核心处方为柴胡、白芍、当归、茯苓、甘草、菟丝子、熟地黄、香附、白术。【结论】中医药治疗肝郁型PCOS重在疏肝健脾、补益肝肾,以达气血冲任调和。Objective Based on the Ancient and Modern Medical Record Cloud Platform,the medication rules of Chinese herbal medicine for the treatment of polycystic ovary syndrome(PCOS)of liver stagnation type were explored.Methods From database inception till December 2023,the medical records of TCM in treating PCOS of liver stagnation type were retrieved from the databases of China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Data Knowledge Service Platform(Wangfang).After that,the data of prescription and TCM syndrome type were extracted,and then a database was constructed.The Ancient and Modern Medical Record Cloud Platform(V2.3.7)was used to conduct statistical analysis of relevant types of liver stagnation,occurrence frequency of Chinese herbal medicines,and the properties and efficacy of Chinese herbal medicines,as well as correlation analysis and clustering analysis for Chinese herbal medicines.The core prescriptions were mined by complex network analysis.Results A total of 108 prescriptions were included in this study,involving 174 Chinese herbal medicines.The syndrome of kidney deficiency and liver stagnation was most frequently seen,and Angelicae Sinensis Radix and Bupleuri Radix were the Chinese herbal medicines used most frequently.The Chinese herbal medicines usually have the meridian tropism of liver,spleen and kidney meridians,and most of them were mild and sweet in the proterties.The Chinese herbal medicines usually have the actions of soothing liver and alleviating depression.A total of 17 herbal groups such as“Angelicae Sinensis Radix-Paeoniae Radix Alba”and“Bupleuri Radix-Paeoniae Radix Alba”were obtained after association analysis,and the cluster analysis yielded four clustering combinations of Chinese herbal medicine.The core prescription was composed of Bupleuri Radix,Paeoniae Radix Alba,Angelicae Sinensis Radix,Poria,Glycyrrhizae Radix et Rhizoma,Cuscutae Semen,Rehmanniae Radix Praeparata,Cyperi Rhizoma,and Atractylodis Macrocephalae Rhizoma

关 键 词：多囊卵巢综合征 肝郁 古今医案云平台 疏肝健脾 补益肝肾 柴胡 白芍 当归 

分 类 号：R271.9[医药卫生—中西医结合]