孕期子宫动脉超声参数、血清PIGF水平与子痫前期风险的相关性研究  

The correlation between uterine artery ultrasound parameters, serum PIGFlevel and the risk of preeclampsia during pregnancy

作　　者：李敏[1] 郑淑敏 张红霞[1] 戴呈呈 刘超[2] 于鹏 LI Min;ZHENG Shumin;ZHANG Hongxia;DAI Chengcheng;LIU Chao;YU Peng(Department of Obstetrics and Gynecology,Qilu Hospital of Shandong University Dezhou Hospital Shandong University,Dezhou,Shandong 253000,China;不详)

机构地区：[1]山东大学齐鲁医院德州医院妇产科,山东德州253000 [2]山东大学齐鲁医院德州医院麻醉手术科

出　　处：《中华全科医学》2025年第2期257-260,共4页Chinese Journal of General Practice

基　　金：山东省医药卫生科技发展计划项目(2019WS019)。

摘　　要：目的 分析在子痫前期患者中子宫动脉超声参数、血清胎盘生长因子(PIGF)水平变化的意义。方法 纳入2022年1月—2023年12月山东大学齐鲁医院德州医院收治的80例子痫前期孕妇为观察组,分为轻度/重度子痫前期亚组,同期30例健康孕妇为对照组。比较各组子宫动脉超声参数[阻力指数(RI)、搏动指数(PI)、血流收缩期与舒张期流速比(S/D)]、血清PIGF;采用logistic回归分析研究子宫动脉超声参数、PIGF与子痫前期的相关性;采用ROC曲线评估子宫动脉超声参数、PIGF对预测子痫前期严重程度的价值。结果 观察组RI(0.62±0.12)、PI(1.64±0.32)、S/D(0.58±0.18)高于对照组(0.56±0.10、1.30±0.17、0.46±0.18),血清PIGF[(33.24±7.36)pg/mL]低于对照组[(50.12±10.10)pg/mL,P<0.05];RI、PI、S/D升高是子痫前期的危险因素,PIGF升高是保护因素(P<0.05);观察组轻度25例,重度55例,重度子痫前期亚组RI、PI、S/D较高,PIGF较低(P<0.05);RI、PI评估子痫前期严重程度的AUC为0.565、0.568(P>0.05),S/D、PIGF、联合检测的AUC为0.685、0.648、0.774(P<0.05)。结论 子痫前期孕妇RI、PI、S/D升高,血清PIGF降低,均与子痫前期的发病相关,联合检测可评估子痫前期严重程度。Objective To analisis significance of uterine artery ultrasound parameters and serum placental growth factor(PIGF)levels in preeclampsia patients.Methods A total of 80 pregnant women with preeclampsia admitted to Dezhou Hospital of Qilu Hospital of Shandong University from January 2022 to December 2023 were included as the observation group and were divided into mild/severe preeclampsia subgroup,and 30 healthy pregnant women during the same period were included as the control group.The ultrasonic parameters of uterine artery[resistance index(RI),pulse index(PI),systolic to diastolic flow velocity ratio(S/D)]and serum PIGF levels were compared;The correlation between uterine artery ultrasound parameters,PIGF,and preeclampsia was analyzed by logistic regression;The receiver operating characteristic curve(ROC)were used to evaluate the value of uterine artery ultrasound parameters and PIGF in the severity of preeclampsia.Results RI(0.62±0.12),PI(1.64±0.32)and S/D(0.58±0.18)in the observation group were higher than those in control group(0.56±0.10,1.30±0.17,0.46±0.18),but serum PIGF[(33.24±7.36)pg/mL]was lower(P<0.05);RI,PI,and S/D were risk factors for preeclampsia,and PIGF was a protective factor(P<0.05).There were 25 mild cases and 55 severe cases in the observation group.RI,PI,and S/D in the severe preeclampsia subgroup were significantly higher,and PIGF was significantly lower(P<0.05);The area under the curve(AUC)of RI and PI in evaluating the severity of preeclampsia were 0.565 and 0.568(P>0.05),and those of S/D,PIGF,and combined detection were 0.685,0.648,and 0.774,respectively(P<0.05).Conclusion RI,PI,and S/D in pregnant women with preeclampsia increase,but serum PIGF levels decrease,which is associated with the onset of preeclampsia,and the combined detection can assess the severity of preeclampsia.

关 键 词：子痫前期 子宫动脉 超声 胎盘生长因子 

分 类 号：R714.244[医药卫生—妇产科学]