早产儿高氧导致脑损伤的研究进展  

Research progress on hyperoxia-induced brain injuryin preterm infants

作　　者：曾孜熠 周美岑 王华 ZENG Ziyi;ZHOU Meicen;WANG Hua(Department of Neonatology,West China Second Hospital of Sichuan University,Chengdu,Sichuan,610041)

机构地区：[1]四川大学华西第二医院新生儿科,四川成都610041

出　　处：《实用临床医药杂志》2025年第1期136-143,共8页Journal of Clinical Medicine in Practice

基　　金：四川省科技厅中央引导地方项目(23ZYZYTS0099)。

摘　　要：新生儿重症监护室(NICU)技术的发展,使得氧疗普遍应用于早产儿抢救治疗中,提高了早产儿存活率。然而,与高氧相关的早产儿脑病(EOP)、早产儿视网膜病(ROP)和支气管肺发育不良(BPD)等并发症严重影响存活早产儿的生存质量。本文综述了高氧导致脑损伤的临床及动物实验研究现状,明确与高氧相关早产儿神经系统损伤可能的表现及机制,为早产儿临床安全用氧决策提供理论依据。With the advances of technology in neonatal intensive care unit(NICU),oxygen therapy in the resuscitation and treatment of preterm infants is widely applied,which significantly improves their survival rates.However,complications associated with hyperoxia,such as early onset preterm encephalopathy(EOP),retinopathy of prematurity(ROP),and bronchopulmonary dysplasia(BPD),severely affect the quality of life of surviving preterm infants.This article reviewed the current clinical and animal experimental research on hyperoxia-induced brain injury,clarifying the potential manifestations and mechanisms of neurological damage related to hyperoxia in preterm infants.The findings provide a theoretical basis for safe oxygen use decisions in clinical practice for preterm infants.

关 键 词：高氧 脑损伤 支气管肺发育不良 早产儿 动物实验 新生儿 

分 类 号：R725.9[医药卫生—儿科] R722.6[医药卫生—临床医学] R34