猪链球菌2型关键毒力因子及诱发疾病机制的研究进展  

Research progress in critical virulence factors of Streptococcus suis serotype 2 and its disease-inducing mechanisms

作　　者：董晨晖 金美君 李建[1] 岳怀宁 刘燕[1] 王豪杰 胡云皓 朱良全[1] DONG Chenhui;JIN Meijun;LI Jian;YUE Huaining;LIU Yan;WANG Haojie;HU Yunhao;ZHU Liangquan(China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《微生物学通报》2025年第1期127-136,共10页Microbiology China

基　　金：国家重点研发计划(2022YFD1800903);中国兽医药品监察所第三批公益性专项(GY202403)。

摘　　要：开展致病机制研究是揭示病原菌引起宿主感染发病规律的重要途径。猪链球菌(Streptococcus suis,SS)是造成全球养猪业重大经济损失的主要病原体之一。在不同SS血清型中,猪链球菌2型(Streptococcus suis serotype 2,SS2)致病性最强,流行最广。本文简述了SS2关键毒力因子情况,重点对SS2引发链球菌中毒休克样综合征(streptococcal toxic shock-like syndrome,STSLS)和脑膜炎的致病机制进行了系统梳理凝练,以期对猪链球菌病防控提供新思路。The research on the disease-inducing mechanisms of pathogens is an important way to reveal the regularity of host infections.Streptococcus suis(SS)is one of the major pathogens causing economic losses in the global pig industry.Among the different SS serotypes,SS serotype 2(SS2)is the most pathogenic and widespread.This paper briefly describes the crucial virulence factors of SS2 and elaborates on the mechanisms of SS2 in inducing streptococcal toxic shock-like syndrome and meningitis,with a view to providing new ideas for the prevention and control of porcine streptococcal diseases.

关 键 词：猪链球菌2型 毒力因子 致病机制 

分 类 号：S852.61[农业科学—基础兽医学]