生理药代动力学模型在毒品研究中的应用  

Application of physiological pharmacokinetic models in drug research

作　　者：曾宪彬 王丹[2,3] 李凯茜 严方 徐鹏[1,2,3] ZENG Xian-bin;WANG Dan;LI Kai-xi;YAN Fang;XU Peng(School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Office of China National Narcotics Control Commssion,China Pharmaceutical University Joint Laboratory on Key Technologies of Narcotics Control,Beijing 100193,China;Key Laboratory of Drug Monitoring and Control,Drug Intelligence and Forensic Center,Ministry of Public Security,Beijing 100193,China)

机构地区：[1]中国药科大学药学院,南京210009 [2]国家禁毒委员会办公室-中国药科大学禁毒关键技术联合实验室,北京100193 [3]公安部禁毒情报技术中心毒品监测管控与禁毒关键技术公安部重点实验室,北京100193

出　　处：《中国药物依赖性杂志》2024年第6期451-457,共7页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金委重点项目(82130056)。

摘　　要：生理药代动力学(physiologically based pharmacokinetic,PBPK)模型能够基于体外实验和动物实验数据模拟化合物在人体体内的吸收、分布、代谢和消除(absorption,distribution,metabolism,and elimination,ADME)过程。尽管从实际临床实验中获取数据存在局限性,但利用PBPK模型可以模拟毒品在人体内的ADME过程,因此PBPK模型为研究毒品药代动力学特性提供有力的工具和方法。本文综述了PBPK模型的构建方法、PBPK模型在部分毒品中的实际应用和一种在毒品PBPK模型开发中很有潜力的模型验证方法,为毒品药代动力学研究提供支持。Physiologically based pharmacokinetic(PBPK)models can simulate the absorption,distribution,metabolism,and elimination(ADME)processes of compounds in the human body,leveraging in vitro and animal experimental data.Given that clinical data for drugs is not readily accessible from actual clinical trials,PBPK models offer a predictive simulation of drug ADME processes in humans.Thus,PBPK models serve as an effective approach for studying drug pharmacokinetics.This article reviews the construction methods of PBPK models,their practical applications in specific drugs,and a promising model validation method in the development of PBPK models for drugs,thereby providing support for the study of drug pharmacokinetics.

关 键 词：基于生理药代动力学模型 毒品 药物代谢动力学 

分 类 号：R969.1[医药卫生—药理学]