祛瘀解毒刮痧膏成型工艺及体外透皮试验的研究  

Research on the Molding Process of Quyu Jiedu Scrapping Ointment and in Vitro Transdermal Test

作　　者：刘相岑 董琳琳 钟以凝 黄金成 陈卫卫 LIU Xiangcen;DONG Linlin;ZHONG Yining;HUANG Jincheng;CHEN Weiwei(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530020,China;Department of Pharmacy,Women and Children's Health Hospital of Guangxi,Nanning 530000,China;Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Nanning 530020,China;The Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Nanning 530020,China;Guangxi Engineering Research Center of Ethnic Medicine Resources and Application,Nanning 530020,China)

机构地区：[1]广西中医药大学药学院,南宁530020 [2]广西壮族自治区妇幼保健院药剂科,南宁530000 [3]广西壮瑶药重点实验室,南宁530020 [4]壮瑶药协同创新中心,南宁530020 [5]广西壮族自治区民族药资源与应用工程研究中心,南宁530020

出　　处：《中国现代应用药学》2024年第21期3010-3015,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：广西中医药重点学科建设项目(GZXK-Z-20-64);广西壮瑶药重点实验室自主研究课题(GXZYZZ2022-18、GXZYZZ2020A-08);壮瑶药协同创新中心研究生科研课题(ZYYDC-08)。

摘　　要：目的优化祛瘀解毒刮痧膏成型工艺。方法以性状、高温稳定性、低温稳定性、离心稳定性、延展性的总评分作为评价指标,采用Box-Behnken响应面试验法优选祛瘀解毒刮痧膏的基质配比;以芍药苷的累积渗透量及渗透动力学参数作为评价指标,通过体外透皮试验确定透皮促渗透剂的类型及含量。结果祛瘀解毒刮痧膏成型工艺处方为药液45.8 g、吐温800.3g、单硬脂酸甘油酯12.2g、蜂蜡5g、羊毛脂9g、白凡士林9g、轻质液体石蜡26g、司盘802.7g、氮酮5.5g、山梨酸0.2g。结论优选的祛瘀解毒刮痧膏成型工艺合理可行,质量稳定可控。OBJECTIVE To optimize the molding process of Quyu Jiedu Scrapping Ointment.METHODS Total scores of characteristics,high temperature stability,low temperature stability,centrifugal stability,and ductility were used as evaluation indicators.The prescription matrix ratio were screened by Box-Behnken response surface method.The cumulative osmotic amount and infiltration dynamic parameters of the paeoniflorin was used as the evaluation index to determine the type and content of the permeable penetration agent through the in vitro permeation test.RESULTS The best molding process of the Quyu Jiedu Scrapping Ointment was determined as follows:45.8 g extract,0.3 g Tween 80,12.2 g glycerin monostearate,5 g beeswax,9 g lanolin,9 g white vaseline,26 g light liquid paraffin,2.7 g emulsifier 80,5.5 g azone and 0.2 g sorbic acid.CONCLUSION The moulding process of the Quyu Jiedu Scrapping Ointment is reasonable and feasible,and the quality is stable and controllable.

关 键 词：祛瘀解毒刮痧膏 成型工艺 响应面试验法 体外透皮试验 

分 类 号：R944.9[医药卫生—药剂学]