基于多指标权重综合评分和正交试验的调经养巢膏提取工艺优选  

Optimization of Extraction Process for Tiaojing Yangchao Ointment Based on Multi-Index Weight Comprehensive Score and Orthogonal Design Test

作　　者：叶欣 赵燕[1] 牛童 金郅力 赵敏[1] 陈艳辉[1] YE Xin;ZHAO Yan;NIU Tong;JIN Zhili;ZHAO Min;CHEN Yanhui(Mianyang Hospital of Traditional Chinese Medicine,Mianyang,Sichuan,China 621000)

机构地区：[1]四川省绵阳市中医医院,四川绵阳621000

出　　处：《中国药业》2025年第3期32-37,共6页China Pharmaceuticals

基　　金：四川省科技计划项目[2021YFS0269];四川中医药高等专科学校中医药重点学科中药化学第一批科研(教改)项目[ZD2020-1]。

摘　　要：目的优选调经养巢膏的提取工艺。方法以加水倍数、提取时间、提取次数为考察因素,以阿魏酸、金丝桃苷、松果菊苷、丹酚酸B、淫羊藿苷的溶出量和出膏率为评价指标,分别采用层次分析(AHP)法、CRITIC法及AHP-CRITIC混合加权法确定各指标的权重系数,采用L_(9)(3^(4))正交试验优选提取工艺。结果优选工艺为复方中药加水煎煮3次,第1次加7倍量水室温浸泡40 min后,煎煮60 min,第2,3次各加5倍量水,煎煮50 min。3次验证试验测得浓缩液中阿魏酸、金丝桃苷、松果菊苷、丹酚酸B、淫羊藿苷的平均溶出量分别为0.0691,0.1307,0.8739,0.8645,0.2175 mg/mL,平均出膏率为40.35%,综合评分为93.35。结论优选工艺科学可行、稳定可控,可为后期调经养巢膏的开发利用提供参考。Objective To optimize the extraction process of Tiaojing Yangchao Ointment.Methods With water addition ratio,extraction time,and extraction times as the evaluation factors,and with the dissolution and extraction rates of ferulic acid,hyperoside,echinacoside,salvianolic acid B,and icariin as the evaluation indexes,the weight coefficient of each index was determined by the Analytic Hierarchy Process(AHP),Criteria Importance Though Intercrieria Correlation(CRITIC)method,and AHP-CRITIC mixed weighting method,respectively.The L_(9)(3^(4))orthogonal test was used to optimize the extraction process.Results The optimal extraction process of the compound traditional Chinese medicine was follows:decocting with water three times;the first time,adding seven times of water,soaking for 40 min under the room temperature,decocting for 60 min;the second and third times,adding five times of water,decocting for 50 min.The average dissolution rates of ferulic acid,hyperoside,echinaside,salvianolic acid B and icariin in the concentrated solution were 0.0691,0.1307,0.8739,0.8645,and 0.2175 mg/mL,respectively,with an average extraction rate of 40.35%,and comprehensive score of 93.35.Conclusion The optimal extraction process is scientifically feasible,stable and controllable,which can provide a reference for the development and utilization of Tiaojing Yangchao Ointment in the later stage.

关 键 词：调经养巢膏 提取工艺 正交试验法 层次分析法 层次分析-CRITIC混合加权法 

分 类 号：R932[医药卫生—生药学] R283.6[医药卫生—药学] R289.5