牡丹皮提取工艺优化  

Optimization of Extraction Process of Moutan Cortex

作　　者：周芳 牛壮伟 袁继承 赵鲁亚[1] ZHOU Fang;NIU Zhuangwei;YUAN Jicheng;ZHAO Luya(Department of Chinese Medicine,Heze Medical College,Heze,Shandong,China 274000)

机构地区：[1]菏泽医学专科学校中医药系,山东菏泽274000

出　　处：《中国药业》2025年第3期49-52,共4页China Pharmaceuticals

基　　金：山东省中医药科技项目[2021Q131]。

摘　　要：目的优化牡丹皮的提取工艺。方法以提取时间、提取次数、加水量为考察因素,以芍药苷和丹皮酚的含量、标准煎剂总抗氧化能力、出膏率为评价指标,采用L_(9)(3^(4))正交试验法筛选最佳提取工艺,并进行验证试验。结果牡丹皮最佳提取工艺为加10倍量水,提取3次,每次90 min。在该提取工艺下,出膏率为(46.2586±0.1886)%,芍药苷和丹皮酚的含量分别为(9.4856±0.0897)mg/g、(18.2244±0.4642)mg/g,总抗氧化能力为(0.5780±0.0022)μmol Trolox/mL。结论优化的提取工艺可行性及稳定性良好,为制备更高品质的牡丹皮配方颗粒提供了参考。Objective To optimize the extraction process of Moutan Cortex.Methods With extraction time,extraction frequency,and water addition as the evaluation factors,and with the content of paeoniflorin and paeonol,the antioxidant capacity of standard decoction,and the extraction rate as the evaluation indexes,the L_(9)(3^(4))orthogonal test was used to screen the optimal extraction process,and validation test was conducted.Results The optimal extraction process of Moutan Cortex was as follows:adding 10 times the amount of water,extracting three times,each time for 90 min.Under this extraction process,the extraction rate was(46.2586±0.1886)%,and the contents of paeoniflorin and paeonol were(9.4856±0.0897)mg/g and(18.2244±0.4642)mg/g,respectively.The total antioxidant capacity was(0.5780±0.0022)μmol Trolox/mL.Conclusion The optimal extraction process has good feasibility and stability,which can provide a reference for the preparation of higher-quality Moutan Cortex Formula Granules.

关 键 词：牡丹皮 芍药苷 丹皮酚 总抗氧化能力 提取工艺 

分 类 号：R932[医药卫生—生药学] R284.2[医药卫生—药学] TQ460.6[化学工程—制药化工]