米安色林治疗伴焦虑和失眠的抑郁症临床观察  

Clinical Observation of Mianserin in the Treatment of Depression Patients with Anxiety and Insomnia

作　　者：苏雯靓 刘浩 李松 文晏[1] SU Wenjing;LIU Hao;LI Song;WEN Yan(Chongqing Mental Health Center,Chongqing,China 401147)

机构地区：[1]重庆市精神卫生中心,重庆401147

出　　处：《中国药业》2025年第3期85-88,共4页China Pharmaceuticals

基　　金：重庆市精神卫生中心院级科研项目[2019-yjkt-09]。

摘　　要：目的探讨米安色林治疗伴焦虑和失眠的抑郁症的临床疗效。方法选取医院2023年2月至8月收治的伴焦虑和失眠的抑郁症患者150例,按随机数字表法分为研究组和对照组,各75例。研究组患者予米安色林治疗,对照组患者予阿普唑仑治疗,均连续治疗4周。结果研究组抑郁症状、睡眠质量治疗总有效率分别为98.67%,94.67%,显著高于对照组的4.00%,81.33%(P<0.05);研究组和对照组的焦虑症状治疗总有效率相当(85.33%比93.33%,P>0.05);治疗第2,4周末,两组患者的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表24项(HAMD-24)、匹兹堡睡眠质量指数量表(PSQI)评分均显著低于治疗前(P<0.05),且研究组HAMD-24和PSQI评分均显著低于对照组(P<0.05);研究组的不良反应发生率为37.33%,显著低于对照组的57.33%(P<0.05)。结论米安色林能有效改善抑郁、焦虑、失眠症状,其缓解焦虑症状的疗效与阿普唑仑相当,改善抑郁和失眠症状的效果较阿普唑仑更佳,且安全性良好。Objective To investigate the clinical efficacy of mianserlin in the treatment of depression patients with anxiety and insomnia.Methods A total of 150 depression patients with anxiety and insomnia admitted to the hospital from February to August 2023 were selected and divided into the study group and the control group by the random number table method,with 75 cases in each group.The patients in the study group were treated with mianserlin,while the patients in the control group were treated with alprazolam.Both groups were treated for four consecutive weeks.Results The total effective rates of depression symptoms and sleep quality in the study group were 98.67% and 94.67%,which were significantly higher than 4.00% and 81.33% in the control group(P<0.05).The total effective rate of anxiety symptom in the study group and the control group was comparable(85.33%vs.93.33%,P>0.05).On the 2nd and 4th weeks of treatment,the Hamilton Anxiety Scale(HAMA),Hamilton Depression Rating Scale 24-item version(HAMD-24),and Pittsburgh Sleep Quality Index(PSQI)scores in the two groups were significantly lower than those before treatment(P<0.05),and the HAMD-24 and PSQI scores in the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group was 37.33%,which was significantly lower than 57.33% in the control group(P<0.05).Conclusion Mianserin can effectively improve symptoms of depression,anxiety,and insomnia.The efficacy of mianserin in relieving anxiety symptoms is comparable to that of alprazolam,while its effect in improving depression and insomnia symptoms is better than that of alprazolam,with good safety.

关 键 词：米安色林 抑郁症 焦虑 失眠 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R971.43[医药卫生—药学]