普伐他汀联合普萘洛尔治疗青少年高血压临床研究  

Clinical Study of Pravastatin Combined with Propranolol in the Treatment of Hypertension in Adolescents

作　　者：李学英 张可凡 魏江 李杰[1] 陈劢[1] LI Xueying;ZHANG Kefan;WEI Jiang;LI Jie;CHEN Mai(The First Division Hospital of Xinjiang Production and Construction Corps,Aksu,Xinjiang,China 843000)

机构地区：[1]新疆生产建设兵团第一师医院,新疆阿克苏843000

出　　处：《中国药业》2025年第3期97-101,共5页China Pharmaceuticals

基　　金：新疆维吾尔自治区自然科学基金[2020D01C413]。

摘　　要：目的探讨普伐他汀联合普萘洛尔治疗青少年高血压的临床疗效,以及对患者左心室质量指数(LVMI)及血清半乳糖凝集素-3(Gal-3)、和肽素(CPP)水平的影响。方法选取医院2020年6月至2023年1月收治的青少年高血压患者138例,按随机数字表法分为观察组和对照组,各69例。两组患者均予普萘洛尔治疗,观察组患者加用普伐他汀治疗,两组患者均连续治疗6个月。结果观察组的总有效率为94.20%,显著高于对照组的81.16%(P<0.05)。治疗后,两组患者的收缩压(SBP)、舒张压(DBP)、24 h SBP标准差(24 h SSD)、24 h SBP变异系数(24 h SCV)、24 h DBP标准差(24 h DSD)、24 h DBP变异系数(24 h DCV)均显著降低(P<0.05),且观察组均显著低于对照组(P<0.05);两组患者的血清内皮素1(ET-1),Gal-3,CPP水平及LVMI均显著降低(P<0.05),NO水平均显著升高(P<0.05),且观察组变化幅度均显著大于对照组(P<0.05)。观察组与对照组的不良反应发生率相当(10.14%比11.59%,P>0.05)。结论普伐他汀联合普萘洛尔治疗青少年高血压的临床疗效较好,可有效控制患者的血压,改善血管内皮功能,调节Gal-3,CPP水平,逆转左心室肥厚,且安全性较高。Objective To investigate the clinical efficacy of pravastatin combined with propranolol in the treatment of hypertension in adolescents,and its effect on left ventricular mass index(LVMI),serum galectin-3(Gal-3),and peptidoglycan(CPP)levels.Methods A total of 138 adolescent patients with hypertension admitted to the hospital from June 2020 to January 2023 were selected and divided into the observation group and the control group by the random number table method,with 69 cases in each group.The patients in the two groups were treated with propranolol,on this basis,the patients in the observation group were additionally treated with pravastatin.Both groups were continuously treated for six months.Results The total effective rate in the observation group was 94.20%,which was significantly higher than 81.16%in the control group(P<0.05).After treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP),24 h SBP standard deviation(24 h SSD),24 h SBP coefficient of variation(24 h SCV),24 h DBP standard deviation(24 h DSD),and 24 h DBP coefficient of variation(24 h DCV)in the two groups significantly decreased(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).The serum levels of endothelin-1(ET-1),Gal-3,and CPP,and the LVMI in the two groups significantly decreased(P<0.05),while the levels of NO in the two groups significantly increased(P<0.05),and the change in the observation group was significantly greater than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was comparable to that in the control group(10.14%vs.11.59%,P>0.05).Conclusion Pravastatin combined with propranolol is effective and safe in the treatment of hypertension in adolescents,which can effectively control blood pressure,improve vascular endothelial function,regulate Gal-3 and CPP levels,and reverse left ventricular hypertrophy.

关 键 词：普伐他汀 普萘洛尔 青少年高血压 左心室质量指数 半乳糖凝集素-3 和肽素 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R972.4[医药卫生—药学]