补肾活血中药改善帕金森病睡眠症状的网状Meta分析  

Net Meta-analysis on Improvement of Sleeping Symptoms in Parkinson's Disease by Chinese Herbal Medicine for Kidney Replenishment and Blood Invigoration

作　　者：李珣 丁琦 夏金言 刘颖 蔡晶 LI Xun;DING Qi;XIA Jinyan;LIU Ying;CAI Jing(School of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China;The Third People's Hospital attached to Fujian University of Traditional Chinese Medicine,Fuzhou 350100,China;School of Traditional Chinese Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China)

机构地区：[1]福建中医药大学中西医结合学院,福建福州350108 [2]福建中医药大学附属第三人民医院,福建福州350100 [3]福建中医药大学中医学院,福建福州350108

出　　处：《海南医科大学学报》2025年第2期131-145,共15页Journal of Hainan Medical University

基　　金：国家自然科学基金(面上项目)(82074507);中医健康管理学联合省级临床重点专科建设项目(老年病科)(XJG2023016);福建省自然科学基金(重点项目)(2023J02023)。

摘　　要：目的:探索补肾活血中药对帕金森病(PD)睡眠症状的临床疗效。方法:计算机检索知网、万方、维普、PubMed、Cochrane Library、Embase、sinomed、Medline等中英文数据库,搜集补肾活血中药治疗PD睡眠的随机对照试验(RCTs),检索时限为建库至2024年7月。由两名研究者通过Note express软件进行文献筛选、数据提取后,采用RevMan5.4进行偏倚风险评估,Stata18.0进行网状Meta分析。结果:共纳入36篇RCTs研究,包括3583例患者。网状Meta分析结果显示在提高临床总有效率较方面,排名前三位分别为平颤颗粒、补肾活血饮、补肾活血汤;在提高帕金森病睡眠量表方面,排名前三位为滋肾平颤颗粒、止颤汤、补肾活血颗粒;在降低匹兹堡睡眠质量指数方面,排名前三位为苁蓉舒痉颗粒、补肾活血汤、补肾活血颗粒;在降低5-羟色胺含量方面,排名前三位为补肾活血通络方、补肾活血颗粒、补肾活血饮;在降低统一帕金森病评分量表精神情绪积分方面,排名前三位为自拟补肾活血汤、滋肾平颤方、补肾活血通络方。在改善不良反应方面,排名前三位为止颤汤、补肾活血疏肝汤、补肾活血颗粒。结论:基于当前证据,证明补肾活血中药可提高治疗PD患者睡眠症状疗效,受纳入研究质量与数量限制,上述研究结果仍需更多大样本、高质量、直接比较的研究验证。Objective:To explore the clinical efficacy of Bushen Huoxue traditional Chinese medicine on sleep symptoms in Parkinson's disease(PD).Methods:Computer searches of Chinese and English databases such as Zhi.com,Wanfang,Wipu,PubMed,Cochrane Library,Embase,sinomed,Medline,etc.were conducted to collect randomised controlled trials(RCTs)on the treatment of Parkinson's disease(PD)sleep by rennon-renal-boosting Chinese herbal medicines with a search timeframe of the period of library construction to July 2024.After literature screening and data extraction by two researchers through Note express software,RevMan 5.4 was used for risk of bias assessment,and Stata 18.0 was used for reticulation Meta-analysis.Results:A totalof 36 studies of RCTs were included,including 3583 patients.The results of reticulated meta-analysis showed that in terms ofimproving the overall clinical effectiveness rate,the top three were ping trembling granules,Bushen Huoxue drink,and BushenHuoxue soup,respectively;in terms of improving the PDSS,the top three were nourishing the kidney and ping trembling granules,stopping trembling soup,and Bushen Huoxue granules;in terms of lowering the PSQI,the top three were Cistanches andrelieving spasm granules,Bushen Huoxue soup,and Bushen Huoxue granules;and in terms of lowering the 5-HT In reducing 5-HT,the top three were Bushen Huoxue circulation formula,Bushen Huoxue granules,and Bushen Huoxue drink;in reducingUPDRSⅠ,the top three were self-designed Bushen Huoxue soup,nourishing the kidney and calming tremor formula,and BushenHuoxue circulation formula.In terms of improvement of adverse reactions,the top three were Stop Fibrillation Soup,NourishingKidney,Activating Blood and Shredding Liver Soup,and Tonifying Kidney,Activating Blood and Promoting Blood Granule.Conclusion:Based on the current evidence,it is proved that Chinese herbs that tonify the kidney and invigorate blood can improvethe efficacy of treating sleep symptoms in patients with PD.Due to the limitation of the quality and number of included s

关 键 词：帕金森病 补肾活血 网状Meta 睡眠 疗效 

分 类 号：R277.7[医药卫生—中医学] G353.1[文化科学—情报学]