尘肺病肺灌洗治疗的有效性与安全性  

The efficacy and safety of therapeutic lung lavage for pneumoconiosis patients

作　　者：徐紫阳 王丽[2] 贺今 XU Ziyang;WANG Li;HE Jin(Shandong First Medical University/Shandong Academy of Medical Sciences,Jinan,Shandong 250062,China)

机构地区：[1]山东第一医科大学/山东省医学科学院,山东济南250062 [2]山东省职业卫生与职业病防治研究院,山东第一医科大学/山东省职业病医院职业性肺病科

出　　处：《中国工业医学杂志》2024年第6期595-598,共4页Chinese Journal of Industrial Medicine

基　　金：山东省自然科学基金(ZR2021MH178);山东省中医药科技项目(M-2023340)。

摘　　要：尘肺为不可逆的进展性肺纤维化疾病,由于尚无逆转肺纤维化的治疗手段,肺灌洗技术成为目前尘肺治疗的重要手段。肺灌洗包括大容量全肺灌洗(WLL)和小容量纤维支气管镜肺泡灌洗(BAL),对其安全性和有效性尚缺乏共识。本文阐述了肺灌洗治疗尘肺的最新进展,对治疗适应证和禁忌证、获益和风险进行总结分析,为临床尘肺病的肺灌洗治疗提供循证依据。Pneumoconiosis is an irreversible and progressive disease of pulmonary fibrosis.Due to the lack of therapeutic means to reverse pulmonary fibrosis,transpulmonary lavage therapy has become an important means of treatment for pneumoconiosis,and pulmonary lavage includes both whole lung lavage(WLL)and bronchoalveolar lavage(BAL),but there is still a lack of consensus on its safety and effectiveness.This article reviews the latest progress of lung lavage for the treatment of pneumoconiosis,and summarizes the indications and contraindications,benefits and risks of its treatment,in order to provide a basis for the effectiveness and safety as well as the clinical benefits of lung lavage for the treatment of pneumoconiosis.

关 键 词：肺灌洗 尘肺 有效性 安全性 

分 类 号：R135.2[医药卫生—劳动卫生]