Modulation of Nicotine-Associated Behaviour in Rats Byμ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell  

作　　者：Feng Zhu Hirosato Kanda Hiroyuki Neyama Yuping Wu Shigeki Kato Di Hu Shaoqi Duan Koichi Noguchi Yasuyoshi Watanabe Kazuto Kobayashi Yi Dai Yilong Cui 

机构地区：[1]Department of Anatomy and Neuroscience,Hyogo Medical University,Nishinomiya,Hyogo,663-8501,Japan [2]Laboratory for Brain-Gut Homeostasis,Hyogo Medical University,Nishinomiya,Hyogo,663-8501,Japan [3]School of Pharmacy,Hyogo Medical University,Kobe,Hyogo,650-8530,Japan School of Pharmacy,Hyogo Medical University,Kobe,Hyogo,650-8530,Japan [4]RIKEN Center for Biosystems Dynamics Research,Kobe,Hyogo,650-0047,Japan [5]Department of Molecular Genetics,Fukushima Medical University Institute of Biomedical Sciences,Fukushima,960-1295,Japan

出　　处：《Neuroscience Bulletin》2024年第12期1826-1842,共17页神经科学通报(英文版)

基　　金：supported by JSPS KAKENHI(24659574,26112003,and 15K14328),and JP 16H06276(AdAMS).

摘　　要：Nicotine addiction is a concern worldwide.Most mechanistic investigations are on nicotine substance dependence properties based on its pharmacological effects.However,no effective therapeutic treatment has been established.Nicotine addiction is reinforced by environments or habits.We demonstrate the neurobiological basis of the behavioural aspect of nicotine addiction.We utilized the conditioned place preference to establish nicotine-associated behavioural preferences(NABP)in rats.Brain-wide neuroimaging analysis revealed that the medial prefrontal cortex(mPFC)was activated and contributed to NABP.Chemogenetic manipulation ofµ-opioid receptor positive(MOR+)neurons in the mPFC or the excitatory outflow to the nucleus accumbens shell(NAcShell)modulated the NABP.Electrophysiological recording confirmed that the MOR+neurons directly regulate the mPFC-NAcShell circuit via GABAA receptors.Thus,the MOR+neurons in the mPFC modulate the formation of behavioural aspects of nicotine addiction via direct excitatory innervation to the NAcShell,which may provide new insight for the development of effective therapeutic strategies.

关 键 词：Nicotine-associated behaviour μ-Opioid receptor Medial prefrontal cortex Nucleus accumbens shell Small-animal neuroimaging 

分 类 号：R965[医药卫生—药理学]