TAF15 Overexpression Impairs Memory in Mice by Inhibiting the Transcription of Npas4  

作　　者：Meijie Ding Dingfeng Li Juan Zhang Qiang Liu 

机构地区：[1]Department of Neurology,The First Affiliated Hospital of USTC,Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Division of Life Sciences and Medicine,Hefei National Research Center for Physical Sciences at the Microscale,University of Science and Technology of China,Hefei,230001,China [2]Neurodegenerative Disorder Research Center,Anhui Province Key Laboratory of Biomedical Aging Research,University of Science and Technology of China,Hefei,230027,China [3]CAS Key Laboratory of Brain Function and Disease,University of Science and Technology of China,Hefei,230027,China [4]Biomedical Sciences and Health Laboratory of Anhui Province,University of Science and Technology of China,Hefei,230027,China

出　　处：《Neuroscience Bulletin》2024年第12期1937-1942,共6页神经科学通报(英文版)

基　　金：supported by the National Key R&D Program of China(2021YFA0804900 and 2020YFA0509300);the National Natural Science Foundation of China(82125009,82330045,82071185,32100794,92149303,and 32121002);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000);a CAS Project for Young Scientists in Basic Research(YSBR-013);Plans for Major Provincial Science&Technology Projects(202303a07020004);the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003);Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYZD20220003);USTC Research Funds of the Double First-Class Initiative.

摘　　要：Dear Editor,Learning-induced expression of activity-dependent genes,especially immediate-early genes(IEGs),is required for the conversion of experience-induced neuronal activity into long-term memory[1].Neuronal Per-Arnt-Sim domain protein 4(Npas4)is one of the most rapidly induced IEGs,functioning as a transcription factor to regulate the activity-dependent expression of other IEGs,such as activityregulated cytoskeleton associated protein(Arc),Fos protooncogene,and early growth response 1(Egrl)[1].

关 键 词：IMMEDIATE FOS TAF 

分 类 号：R338.64[医药卫生—人体生理学]